Projects per year
Abstract
Polyacrylic-acid-coated ultra-small super-paramagnetic iron oxide nanoparticles were surface-modified with low-molecular-weight sulfobetaines or 3-(diethylamino)propylamine in order to generate nanoparticles with zwitterionic character (ZW-NPs). The ZW-NPs proved highly resistant to serum protein corona formation invitro, as revealed by atomic force microscopy, SDS-PAGE and proteomics analysis, and exhibited low cytotoxicity towards A431 and HEK293 cells. The presence of unreacted carboxylic acid groups enabled additional functionalization with fluorescent (Cy5) and radioactive [64Cu-dmptacn; dmptacn=1,4-bis(2-pyridinylmethyl)-1,4,7-triazacyclononane] moieties. Overall, the ZW-NPs represent promising platforms for the development of new multimodal diagnostic/therapeutic agents possessing "stealth" properties.
Original language | English |
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Pages (from-to) | 638–646 |
Number of pages | 9 |
Journal | ChemPlusChem |
Volume | 82 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Iron oxide nanoparticles
- Multimodal imaging
- Protein corona
- Proteomics
- Zwitterions
Projects
- 2 Finished
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Expanding the molecular tool set for structural studies of proteins and their complexes
Graham, B.
Australian Research Council (ARC)
1/01/14 → 31/12/17
Project: Research
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Functionalized Nanomaterials for Application as Multimodal Cancer Imaging Agents
Spiccia, L.
Australian Research Council (ARC), Monash University
3/01/13 → 1/01/17
Project: Research
Equipment
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Centre for Electron Microscopy (MCEM)
Flame Sorrell (Manager) & Peter Miller (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility