Zinc metabolism in airway epithelium and airway inflammation: Basic mechanisms and clinical targets. A review

Peter D. Zalewski, Ai Q. Truong-Tran, Dion Grosser, Lata Jayaram, Chiara Murgia, Richard E. Ruffin

Research output: Contribution to journalReview ArticleResearchpeer-review

123 Citations (Scopus)

Abstract

In addition to basic housekeeping roles in metalloenzymes and transcription factors, dietary zinc (Zn) is an important immunoregulatory agent, growth cofactor, and cytoprotectant with anti-oxidant, anti-apoptotic, and anti-inflammatory roles. These properties of Zn are of particular importance in maintaining homeostasis of epithelial tissues which are at the front line of defense. This review is about the role of Zn in airway epithelium (AE). The first part focuses on the cellular biology of Zn, and what is known about its distribution and function in AE. The second part of the review considers evidence for altered Zn metabolism in asthma and other chronic diseases of airway inflammation. Important issues arise from a potential therapeutic perspective as to the optimal ways to monitor circulating and epithelial Zn levels in patients and the most effective means of supplementing these levels.

Original languageEnglish
Pages (from-to)127-149
Number of pages23
JournalPharmacology and Therapeutics
Volume105
Issue number2
DOIs
Publication statusPublished - 1 Feb 2005
Externally publishedYes

Keywords

  • Airway epithelium
  • Airway inflammation
  • Apoptosis
  • Asthma
  • Zinc
  • Zinc deficiency
  • Zinc supplementation
  • Zinquin

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