Zinc-coordination and C-peptide complexation: A potential mechanism for the endogenous inhibition of IAPP aggregation

Xinwei Ge, Aleksandr Kakinen, Esteban N. Gurzov, Wen Yang, Lokman Pang, Emily H. Pilkington, Praveen Nedumpully-Govindan, Pengyu Chen, Frances Separovic, Thomas P. Davis, Pu Chun Ke, Feng Ding

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20 Citations (Scopus)

Abstract

Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-peptide might be important for the endogenous inhibition of IAPP aggregation.

Original languageEnglish
Pages (from-to)9394-9397
Number of pages4
JournalChemical Communications
Volume53
Issue number68
DOIs
Publication statusPublished - 2017

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