Zinc-coordination and C-peptide complexation: A potential mechanism for the endogenous inhibition of IAPP aggregation

Xinwei Ge, Aleksandr Kakinen, Esteban N. Gurzov, Wen Yang, Lokman Pang, Emily H. Pilkington, Praveen Nedumpully-Govindan, Pengyu Chen, Frances Separovic, Thomas P. Davis, Pu Chun Ke, Feng Ding

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Abstract

Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-peptide might be important for the endogenous inhibition of IAPP aggregation.

Original languageEnglish
Pages (from-to)9394-9397
Number of pages4
JournalChemical Communications
Volume53
Issue number68
DOIs
Publication statusPublished - 2017

Cite this

Ge, X., Kakinen, A., Gurzov, E. N., Yang, W., Pang, L., Pilkington, E. H., Nedumpully-Govindan, P., Chen, P., Separovic, F., Davis, T. P., Ke, P. C., & Ding, F. (2017). Zinc-coordination and C-peptide complexation: A potential mechanism for the endogenous inhibition of IAPP aggregation. Chemical Communications, 53(68), 9394-9397. https://doi.org/10.1039/c7cc04291d