@article{1f1c36cfa3064412a5d0cdb8f3645c7b,
title = "ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer",
abstract = "Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.",
author = "Arpita Poddar and Suneela Pyreddy and Francesco Carraro and Sudip Dhakal and Andrea Rassell and Field, {Matthew R.} and Reddy, {T. Srinivasa} and Paolo Falcaro and Doherty, {Cara M.} and Ravi Shukla",
note = "Funding Information: A. P. acknowledges joint RMIT-CSIRO PhD scholarship and funding provided by Australian Nanotechnology Network through OTF scheme. C. M. D. acknowledges the Veski Inspiring Women Fellowship. Dr Mugdha Joglekar, NHMRC-CTC, University of Sydney, is acknowledged for help in qPCR data analysis. R. S. acknowledges Ian Potter Foundation in establishing Sir Ian Potter NanoBioSensing Facility and the support of ERASMUS program that enabled his visit to Falcaro labs in TU Graz. RMIT Micro Nano Research (MNRF) and Microscopy & Microanalysis (RMMF) facilities are acknowledged for technical assistance. A. R. acknowledges support from ANAT in the form of synapse science art residency. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2020",
month = dec,
day = "21",
doi = "10.1039/d0cc06241c",
language = "English",
volume = "56",
pages = "15406--15409",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "The Royal Society of Chemistry",
number = "98",
}
