Zidovudine

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Abstract

Zidovudine, or 3'-azido-3‘deoxythymidine, formerly known as azidothymidine (AZT; BW A509U), is an analog of the nucleoside thymidine. Zidovudine is a potent inhibitor of the HIV reverse transcriptase and has proven efficacy in the treatment and prevention of HIV infection. It was the first antiretroviral compound to be licensed for the treatment of people infected with HIV. The compound was synthesized much earlier, however, by Horwitz and colleagues (1964) and subsequently used in anticancer research.

Original languageEnglish
Title of host publicationKucers the Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs
EditorsM. Lindsay Grayson
Place of PublicationBoca Raton FL USA
PublisherCRC Press
Pages3657-3697
Number of pages41
Edition7th
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
Publication statusPublished - 2 Oct 2017

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