Xiaoxuming Decoction: A Traditional Herbal Recipe for Stroke With Emerging Therapeutic Mechanisms

Qian Zhang, Yue Wang, Aiwen Chen, Xinwei Huang, Qianyu Dong, Zhen Li, Xiaofei Gao, Tingmei Wu, Wanrong Li, Peilin Cong, Hanxi Wan, Danqing Dai, Mengfan He, Huazheng Liang, Shaoshi Wang, Lize Xiong

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)


Xiaoxuming decoction (XXMD) has been traditionally used to manage stroke though debates on its clinical efficacy were present in the history. Till nowadays, it is still one of the most commonly used herbal recipes for stroke. One of the reasons is that a decent proportion of ischemic stroke patients still have residue symptoms even after thrombolysis with rt-PA or endovascular thrombectomy. Numerous clinical studies have shown that XXMD is an effective alternative therapy not only at the acute stage, but also at the chronic sequelae stage of ischemic stroke. Modern techniques have isolated groups of compounds from XXMD which have shown therapeutic effects, such as dilating blood vessels, inhibiting thrombosis, suppressing oxidative stress, attenuating nitric oxide induced damage, protecting the blood brain barrier and the neurovascular unit. However, which of the active compounds is responsible for its therapeutic effects is still unknown. Emerging studies have screened and tested these active compounds aiming to find individual compounds that can be used as drugs to treat stroke. The present study summarized both clinical evidence of XXMD in managing stroke and experimental evidence on its molecular mechanisms that have been reported recently using advanced techniques. A new perspective has also been discussed with an aim to provide new targets that can be used for screening active compounds from XXMD.

Original languageEnglish
Article number802381
Number of pages9
JournalFrontiers in Pharmacology
Publication statusPublished - 14 Dec 2021
Externally publishedYes


  • active compound
  • effective compound group
  • ischemic stroke
  • molecular mechanism
  • pericytes
  • xiaoxuming decoction

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