TY - JOUR
T1 - X-ray-activated persistent luminescence nanomaterials for NIR-II imaging
AU - Pei, Peng
AU - Chen, Ying
AU - Sun, Caixia
AU - Fan, Yong
AU - Yang, Yanmin
AU - Liu, Xuan
AU - Lu, Lingfei
AU - Zhao, Mengyao
AU - Zhang, Hongxin
AU - Zhao, Dongyuan
AU - Liu, Xiaogang
AU - Zhang, Fan
N1 - Funding Information:
F.Z. and D.Z. acknowledge support from the National Key R&D Program of China (grant no. 2017YFA0207303). F.Z. and D.Z. acknowledge support from the National Natural Science Foundation of China (NSFC, grant nos 22088101 and 51961145403). F.Z. acknowledges support by the National Natural Science Foundation of China (NSFC, grant no. 21725502) and the Research Program of Science and Technology Commission of Shanghai Municipality (grant no. 20JC1411700). Y.F. acknowledges support from the National Natural Science Foundation of China (grant no. 21904023) and the Research Program of Science and Technology Commission of Shanghai Municipality (grant no. 19490713100), Y.Y. acknowledges support from the National Natural Science Foundation of China (grant no. 11974097) and H.Z. acknowledges support from the Research Program of Science and Technology Commission of Shanghai Municipality (grant no. 20490710600).
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2021/9
Y1 - 2021/9
N2 - Persistent luminescence is not affected by background autofluorescence, and thus holds the promise of high-contrast bioimaging. However, at present, persistent luminescent materials for in vivo imaging are mainly bulk crystals characterized by a non-uniform size and morphology, inaccessible core–shell structures and short emission wavelengths. Here we report a series of X-ray-activated, lanthanide-doped nanoparticles with an extended emission lifetime in the second near-infrared window (NIR-II, 1,000–1,700 nm). Core–shell engineering enables a tunable NIR-II persistent luminescence, which outperforms NIR-II fluorescence in signal-to-noise ratios and the accuracy of in vivo multiplexed encoding and multilevel encryption, as well as in resolving mouse abdominal vessels, tumours and ureters in deep tissue (~2–4 mm), with up to fourfold higher signal-to-noise ratios and a threefold greater sharpness. These rationally designed nanoparticles also allow the high-contrast multiplexed imaging of viscera and multimodal NIR-II persistent luminescence–magnetic resonance–positron emission tomography imaging of murine tumours.
AB - Persistent luminescence is not affected by background autofluorescence, and thus holds the promise of high-contrast bioimaging. However, at present, persistent luminescent materials for in vivo imaging are mainly bulk crystals characterized by a non-uniform size and morphology, inaccessible core–shell structures and short emission wavelengths. Here we report a series of X-ray-activated, lanthanide-doped nanoparticles with an extended emission lifetime in the second near-infrared window (NIR-II, 1,000–1,700 nm). Core–shell engineering enables a tunable NIR-II persistent luminescence, which outperforms NIR-II fluorescence in signal-to-noise ratios and the accuracy of in vivo multiplexed encoding and multilevel encryption, as well as in resolving mouse abdominal vessels, tumours and ureters in deep tissue (~2–4 mm), with up to fourfold higher signal-to-noise ratios and a threefold greater sharpness. These rationally designed nanoparticles also allow the high-contrast multiplexed imaging of viscera and multimodal NIR-II persistent luminescence–magnetic resonance–positron emission tomography imaging of murine tumours.
UR - https://www.scopus.com/pages/publications/85107470889
U2 - 10.1038/s41565-021-00922-3
DO - 10.1038/s41565-021-00922-3
M3 - Article
C2 - 34112994
AN - SCOPUS:85107470889
SN - 1748-3387
VL - 16
SP - 1011
EP - 1018
JO - Nature Nanotechnology
JF - Nature Nanotechnology
IS - 9
ER -