Wound management using porous silicon

Steven J.P. McInnes; Christopher T. Turner; Allison J. Cowin; Nicolas H. Voelcker

doi:10.1007/978-3-319-71381-6_131

Wound management using porous silicon

Steven J.P. McInnes, Christopher T. Turner, Allison J. Cowin, Nicolas H. Voelcker

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

Abstract

Wound healing is a critically important but biochemically complex process often requiring intense or prolonged medical intervention to achieve effective clinical outcomes. The increasing prevalence of chronic nonhealing wounds places a significant burden on a patient's quality of life as well as large financial strain on healthcare providers, especially as the treatment options are limited. There is strong potential for "smart" bandages with the ability to both diagnose and deliver therapies to chronic wounds. The potential uses and development of porous silicon structures and devices with regard to biomarker detection, temperature and pH monitoring, infection control, and therapeutic delivery to wounds are extensively reviewed here and a future perspective on the advantages of progressing to theranostic wound dressings is also provided.

Original language	English
Title of host publication	Handbook of Porous Silicon
Subtitle of host publication	Second Edition
Editors	Leigh Canham
Place of Publication	Cham Switzerland
Publisher	Springer
Pages	1433-1452
Number of pages	20
Volume	2
Edition	2
ISBN (Electronic)	9783319713816, 9783319713809
ISBN (Print)	9783319713793
DOIs	https://doi.org/10.1007/978-3-319-71381-6_131
Publication status	Published - 4 Jul 2018
Externally published	Yes

Keywords

Acute wounds
Bacterial detection
Bacterial infection
Biomarkers for ischemic chronic wounds
Biomolecule detection system
Chronic wound monitoring
Chronic wounds
Clotting
Hemostasis
Ischemia
Matrix metalloproteinase
Moisture sensors
Nitric oxide
Odor sensors
pH sensors
Photoluminescence
Porous silicon
Protease activity detection
Small interfering RNA (siRNA)
Temperature sensors
Thermally hydrocarbonized pSi
Tumor necrosis factor-α (TNF-α)
Wound repair

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10.1007/978-3-319-71381-6_131

Cite this

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title = "Wound management using porous silicon",

abstract = "Wound healing is a critically important but biochemically complex process often requiring intense or prolonged medical intervention to achieve effective clinical outcomes. The increasing prevalence of chronic nonhealing wounds places a significant burden on a patient's quality of life as well as large financial strain on healthcare providers, especially as the treatment options are limited. There is strong potential for {"}smart{"} bandages with the ability to both diagnose and deliver therapies to chronic wounds. The potential uses and development of porous silicon structures and devices with regard to biomarker detection, temperature and pH monitoring, infection control, and therapeutic delivery to wounds are extensively reviewed here and a future perspective on the advantages of progressing to theranostic wound dressings is also provided.",

keywords = "Acute wounds, Bacterial detection, Bacterial infection, Biomarkers for ischemic chronic wounds, Biomolecule detection system, Chronic wound monitoring, Chronic wounds, Clotting, Hemostasis, Ischemia, Matrix metalloproteinase, Moisture sensors, Nitric oxide, Odor sensors, pH sensors, Photoluminescence, Porous silicon, Protease activity detection, Small interfering RNA (siRNA), Temperature sensors, Thermally hydrocarbonized pSi, Tumor necrosis factor-α (TNF-α), Wound repair",

author = "McInnes, {Steven J.P.} and Turner, {Christopher T.} and Cowin, {Allison J.} and Voelcker, {Nicolas H.}",

year = "2018",

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doi = "10.1007/978-3-319-71381-6_131",

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AU - McInnes, Steven J.P.

AU - Turner, Christopher T.

AU - Cowin, Allison J.

AU - Voelcker, Nicolas H.

PY - 2018/7/4

Y1 - 2018/7/4

N2 - Wound healing is a critically important but biochemically complex process often requiring intense or prolonged medical intervention to achieve effective clinical outcomes. The increasing prevalence of chronic nonhealing wounds places a significant burden on a patient's quality of life as well as large financial strain on healthcare providers, especially as the treatment options are limited. There is strong potential for "smart" bandages with the ability to both diagnose and deliver therapies to chronic wounds. The potential uses and development of porous silicon structures and devices with regard to biomarker detection, temperature and pH monitoring, infection control, and therapeutic delivery to wounds are extensively reviewed here and a future perspective on the advantages of progressing to theranostic wound dressings is also provided.

AB - Wound healing is a critically important but biochemically complex process often requiring intense or prolonged medical intervention to achieve effective clinical outcomes. The increasing prevalence of chronic nonhealing wounds places a significant burden on a patient's quality of life as well as large financial strain on healthcare providers, especially as the treatment options are limited. There is strong potential for "smart" bandages with the ability to both diagnose and deliver therapies to chronic wounds. The potential uses and development of porous silicon structures and devices with regard to biomarker detection, temperature and pH monitoring, infection control, and therapeutic delivery to wounds are extensively reviewed here and a future perspective on the advantages of progressing to theranostic wound dressings is also provided.

KW - Acute wounds

KW - Bacterial detection

KW - Bacterial infection

KW - Biomarkers for ischemic chronic wounds

KW - Biomolecule detection system

KW - Chronic wound monitoring

KW - Chronic wounds

KW - Clotting

KW - Hemostasis

KW - Ischemia

KW - Matrix metalloproteinase

KW - Moisture sensors

KW - Nitric oxide

KW - Odor sensors

KW - pH sensors

KW - Photoluminescence

KW - Porous silicon

KW - Protease activity detection

KW - Small interfering RNA (siRNA)

KW - Temperature sensors

KW - Thermally hydrocarbonized pSi

KW - Tumor necrosis factor-α (TNF-α)

KW - Wound repair

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U2 - 10.1007/978-3-319-71381-6_131

DO - 10.1007/978-3-319-71381-6_131

M3 - Chapter (Book)

AN - SCOPUS:85053944140

SN - 9783319713793

VL - 2

SP - 1433

EP - 1452

BT - Handbook of Porous Silicon

A2 - Canham, Leigh

PB - Springer

CY - Cham Switzerland

ER -

Wound management using porous silicon

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Keywords

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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Wound management using porous silicon

Abstract

Keywords

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Cite this