Wound management using porous silicon

Steven J.P. McInnes, Christopher T. Turner, Allison J. Cowin, Nicolas H. Voelcker

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Wound healing is a critically important but biochemically complex process often requiring intense or prolonged medical intervention to achieve effective clinical outcomes. The increasing prevalence of chronic nonhealing wounds places a significant burden on a patient's quality of life as well as large financial strain on healthcare providers, especially as the treatment options are limited. There is strong potential for "smart" bandages with the ability to both diagnose and deliver therapies to chronic wounds. The potential uses and development of porous silicon structures and devices with regard to biomarker detection, temperature and pH monitoring, infection control, and therapeutic delivery to wounds are extensively reviewed here and a future perspective on the advantages of progressing to theranostic wound dressings is also provided.

Original languageEnglish
Title of host publicationHandbook of Porous Silicon
Subtitle of host publicationSecond Edition
EditorsLeigh Canham
Place of PublicationCham Switzerland
PublisherSpringer
Pages1433-1452
Number of pages20
Volume2
Edition2
ISBN (Electronic)9783319713816, 9783319713809
ISBN (Print)9783319713793
DOIs
Publication statusPublished - 4 Jul 2018
Externally publishedYes

Keywords

  • Acute wounds
  • Bacterial detection
  • Bacterial infection
  • Biomarkers for ischemic chronic wounds
  • Biomolecule detection system
  • Chronic wound monitoring
  • Chronic wounds
  • Clotting
  • Hemostasis
  • Ischemia
  • Matrix metalloproteinase
  • Moisture sensors
  • Nitric oxide
  • Odor sensors
  • pH sensors
  • Photoluminescence
  • Porous silicon
  • Protease activity detection
  • Small interfering RNA (siRNA)
  • Temperature sensors
  • Thermally hydrocarbonized pSi
  • Tumor necrosis factor-α (TNF-α)
  • Wound repair

Cite this

McInnes, S. J. P., Turner, C. T., Cowin, A. J., & Voelcker, N. H. (2018). Wound management using porous silicon. In L. Canham (Ed.), Handbook of Porous Silicon: Second Edition (2 ed., Vol. 2, pp. 1433-1452). Springer. https://doi.org/10.1007/978-3-319-71381-6_131