TY - JOUR
T1 - Wound healing in foetal sheep
T2 - a histological and electron microscope study
AU - Horne, R. S.C.
AU - Hurley, J. V.
AU - Crowe, D. M.
AU - Ritz, M.
AU - O'Brien, B. Mc C.
AU - Arnold, L. I.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - A study was made of the healing of excised, unsutured and sutured skin wounds in foetal sheep of 75, 90 and 120 days gestation and of wounds in newborn lambs and adult ewes. Foetal and postnatal wounds were found to heal in a very similar way. At each stage of development studied, excised wounds contract rapidly and histological and electron microscope examination demonstrates formation of granulation tissue and its maturation to scar tissue in all types of wound. Examination of polyvinyl sponges 7 and 14 days after subcutaneous implantation confirms the ability of foetal sheep to form vascularised scar tissue. The cellular inflammatory response to wounding is much less prominent in foetal than in postnatal sheep, the number and type of extravascular cells reflecting the changes in blood leucocyte content during development. From a very early stage foetal sheep react to insoluble irritants by the formation of multinucleate giant cells.
AB - A study was made of the healing of excised, unsutured and sutured skin wounds in foetal sheep of 75, 90 and 120 days gestation and of wounds in newborn lambs and adult ewes. Foetal and postnatal wounds were found to heal in a very similar way. At each stage of development studied, excised wounds contract rapidly and histological and electron microscope examination demonstrates formation of granulation tissue and its maturation to scar tissue in all types of wound. Examination of polyvinyl sponges 7 and 14 days after subcutaneous implantation confirms the ability of foetal sheep to form vascularised scar tissue. The cellular inflammatory response to wounding is much less prominent in foetal than in postnatal sheep, the number and type of extravascular cells reflecting the changes in blood leucocyte content during development. From a very early stage foetal sheep react to insoluble irritants by the formation of multinucleate giant cells.
UR - http://www.scopus.com/inward/record.url?scp=0026689596&partnerID=8YFLogxK
U2 - 10.1016/0007-1226(92)90001-E
DO - 10.1016/0007-1226(92)90001-E
M3 - Article
C2 - 1638284
AN - SCOPUS:0026689596
SN - 0007-1226
VL - 45
SP - 333
EP - 344
JO - British Journal of Plastic Surgery
JF - British Journal of Plastic Surgery
IS - 5
ER -