Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp

Nigel Keith Stepto, Samantha Cassar, Anju Elizabeth Joham, Samantha Kate Hutchison, Cheryce Lee Harrison, Rebecca Goldstein, Helena Jane Teede

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433 Citations (Scopus)


Using a cross-sectional study design, 20 overweight and 20 lean PCOS (Rotterdam criteria), 14 overweight and 19 lean body mass index (BMI)-matched control non-PCOS women underwent clinical measures of IR after a 3-month withdrawal of insulin sensitizers and the oral contraceptive pill. In an academic clinic setting, glucose infusion rate (GIR) on euglycaemic-hyperinsulinaemic clamp was investigated as a marker of insulin sensitivity.
Original languageEnglish
Pages (from-to)777 - 784
Number of pages8
JournalHuman Reproduction
Issue number3
Publication statusPublished - 2013

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