Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp

Nigel Keith Stepto, Samantha Cassar, Anju Elizabeth Joham, Samantha Kate Hutchison, Cheryce Lee Harrison, Rebecca Goldstein, Helena Jane Teede

Research output: Contribution to journalArticleResearchpeer-review

323 Citations (Scopus)

Abstract

Using a cross-sectional study design, 20 overweight and 20 lean PCOS (Rotterdam criteria), 14 overweight and 19 lean body mass index (BMI)-matched control non-PCOS women underwent clinical measures of IR after a 3-month withdrawal of insulin sensitizers and the oral contraceptive pill. In an academic clinic setting, glucose infusion rate (GIR) on euglycaemic-hyperinsulinaemic clamp was investigated as a marker of insulin sensitivity.
Original languageEnglish
Pages (from-to)777 - 784
Number of pages8
JournalHuman Reproduction
Volume28
Issue number3
DOIs
Publication statusPublished - 2013

Cite this