Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp

Nigel Keith Stepto; Samantha Cassar; Anju Elizabeth Joham; Samantha Kate Hutchison; Cheryce Lee Harrison; Rebecca Goldstein; Helena Jane Teede

doi:10.1093/humrep/des463

Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp

Nigel Keith Stepto, Samantha Cassar, Anju Elizabeth Joham, Samantha Kate Hutchison, Cheryce Lee Harrison, Rebecca Goldstein, Helena Jane Teede

Health Systems Services & Policy

Research output: Contribution to journal › Article › Research › peer-review

433 Citations (Scopus)

Abstract

Using a cross-sectional study design, 20 overweight and 20 lean PCOS (Rotterdam criteria), 14 overweight and 19 lean body mass index (BMI)-matched control non-PCOS women underwent clinical measures of IR after a 3-month withdrawal of insulin sensitizers and the oral contraceptive pill. In an academic clinic setting, glucose infusion rate (GIR) on euglycaemic-hyperinsulinaemic clamp was investigated as a marker of insulin sensitivity.

Original language	English
Pages (from-to)	777 - 784
Number of pages	8
Journal	Human Reproduction
Volume	28
Issue number	3
DOIs	https://doi.org/10.1093/humrep/des463
Publication status	Published - 2013

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abstract = "Using a cross-sectional study design, 20 overweight and 20 lean PCOS (Rotterdam criteria), 14 overweight and 19 lean body mass index (BMI)-matched control non-PCOS women underwent clinical measures of IR after a 3-month withdrawal of insulin sensitizers and the oral contraceptive pill. In an academic clinic setting, glucose infusion rate (GIR) on euglycaemic-hyperinsulinaemic clamp was investigated as a marker of insulin sensitivity.",

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AU - Stepto, Nigel Keith

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AU - Joham, Anju Elizabeth

AU - Hutchison, Samantha Kate

AU - Harrison, Cheryce Lee

AU - Goldstein, Rebecca

AU - Teede, Helena Jane

PY - 2013

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N2 - Using a cross-sectional study design, 20 overweight and 20 lean PCOS (Rotterdam criteria), 14 overweight and 19 lean body mass index (BMI)-matched control non-PCOS women underwent clinical measures of IR after a 3-month withdrawal of insulin sensitizers and the oral contraceptive pill. In an academic clinic setting, glucose infusion rate (GIR) on euglycaemic-hyperinsulinaemic clamp was investigated as a marker of insulin sensitivity.

AB - Using a cross-sectional study design, 20 overweight and 20 lean PCOS (Rotterdam criteria), 14 overweight and 19 lean body mass index (BMI)-matched control non-PCOS women underwent clinical measures of IR after a 3-month withdrawal of insulin sensitizers and the oral contraceptive pill. In an academic clinic setting, glucose infusion rate (GIR) on euglycaemic-hyperinsulinaemic clamp was investigated as a marker of insulin sensitivity.

UR - http://humrep.oxfordjournals.org/content/28/3/777.full.pdf

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DO - 10.1093/humrep/des463

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JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

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ER -

Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp

Abstract

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