Women versus men with chronic atrial fibrillation: insights from the Standard versus Atrial Fibrillation spEcific managemenT studY (SAFETY)

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Abstract

We screened 2,438 patients with AF and recruited 335 into SAFETY. Of these, 48.1 were women who were, on average, 5 years older than their male counterparts. Women and men displayed divergent antecedent profiles, with women having a higher thrombo-embolic risk but being prescribed similar treatment regimens. More women than men presented to hospital with co-morbid thyroid dysfunction, depression, renal impairment and obesity. In contrast, more men presented with coronary artery disease (CAD) and/or chronic obstructive pulmonary disease (COPD). Even when data was age-adjusted, women were more likely to live alone (odds ratio [OR] 2.33; 95 confidence interval [CI] 1.47 to 3.69), have non-tertiary education (OR 2.69; 95 CI 1.61 to 4.48) and be symptomatic (OR 1.93; 95 CI 1.06 to 3.52).Conclusion:Health care providers should be cognisant of gender-specific differences in an attempt to individualise and, hence, optimise the management of patients with chronic AF and reduce potential morbidity and mortality.
Original languageEnglish
Article numbere65795
Number of pages9
JournalPLoS ONE
Volume8
Issue number5
DOIs
Publication statusPublished - 2013

Cite this