TY - JOUR
T1 - Wolbachia pipientis: an expanding bag of tricks to explore for disease control
AU - Cook, Peter
AU - McGraw, Elizabeth
PY - 2010
Y1 - 2010
N2 - Wolbachia pipientis are maternally inherited, endosymbiotic bacteria that are widespread among insects. Two recent studies have demonstrated that Wolbachia inhibits the ability of medically significant pathogens, including filarial nematodes, dengue virus and Plasmodium to form infections in the mosquito vector, Aedes aegypti. We highlight the added value of these traits for Wolbachia based biocontrol strategies and evaluate the evidence for the idea that the insect immune response is responsible for the pathogen inhibition.
AB - Wolbachia pipientis are maternally inherited, endosymbiotic bacteria that are widespread among insects. Two recent studies have demonstrated that Wolbachia inhibits the ability of medically significant pathogens, including filarial nematodes, dengue virus and Plasmodium to form infections in the mosquito vector, Aedes aegypti. We highlight the added value of these traits for Wolbachia based biocontrol strategies and evaluate the evidence for the idea that the insect immune response is responsible for the pathogen inhibition.
UR - http://ac.els-cdn.com/S147149221000108X/1-s2.0-S147149221000108X-main.pdf?_tid=ccb8094f8150e3608729d18f26fd8451&acdnat=1332112387_68494c84700c8b740d72
U2 - 10.1016/j.pt.2010.05.006
DO - 10.1016/j.pt.2010.05.006
M3 - Article
VL - 26
SP - 373
EP - 375
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 8
ER -