Wnt signalling in gastrointestinal epithelial stem cells

Dustin J. Flanagan; Chloe R. Austin; Elizabeth Vincan; Toby J. Phesse

doi:10.3390/genes9040178

Wnt signalling in gastrointestinal epithelial stem cells

Dustin J. Flanagan
, Chloe R. Austin
, Elizabeth Vincan
, Toby J. Phesse

Research output: Contribution to journal › Review Article › Research › peer-review

76 Citations (Scopus)

Abstract

Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is critical for embryonic development. Stem cells are defined by their ability for self-renewal and the ability to be able to give rise to differentiated progeny. Consequently, they are essential for the homeostasis of many organs including the gastrointestinal tract. This review will describe the huge advances in our understanding of how stem cell functions in the gastrointestinal tract are regulated by Wnt signalling, including how deregulated Wnt signalling can hijack these functions to transform cells and lead to cancer.

Original language	English
Article number	178
Number of pages	32
Journal	Genes
Volume	9
Issue number	4
DOIs	https://doi.org/10.3390/genes9040178
Publication status	Published - Apr 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Epithelium
Gastric
Intestine
Plasticity
Regeneration
Stem cells
Stomach
Wnt signalling

Access to Document

10.3390/genes9040178Licence: CC BY

Cite this

@article{b4cde9e5d9e04fb4ad8d4a3543e845ba,

title = "Wnt signalling in gastrointestinal epithelial stem cells",

abstract = "Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is critical for embryonic development. Stem cells are defined by their ability for self-renewal and the ability to be able to give rise to differentiated progeny. Consequently, they are essential for the homeostasis of many organs including the gastrointestinal tract. This review will describe the huge advances in our understanding of how stem cell functions in the gastrointestinal tract are regulated by Wnt signalling, including how deregulated Wnt signalling can hijack these functions to transform cells and lead to cancer.",

keywords = "Cancer, Epithelium, Gastric, Intestine, Plasticity, Regeneration, Stem cells, Stomach, Wnt signalling",

author = "Flanagan, \{Dustin J.\} and Austin, \{Chloe R.\} and Elizabeth Vincan and Phesse, \{Toby J.\}",

note = "Funding Information: The authors wish to thank Gavan Mitchell for helping generate the figures in this manuscript. Funding is gratefully acknowledged from the following; National Health and Medical Research Council of Australia (NHMRC) project grants (566679 and APP1099302 awarded to E.V.); Melbourne Health project grants (605030 and PG-002 awarded to E.V./T.J.P.), and an Early Career Researcher grant (GIA-033) awarded to D.J.F.; Cancer Council of Victoria project grants (CCV, APP1020716) awarded to E.V. and T.J.P., CCV Fellowship awarded to D.J.F. and Cardiff University Research Fellowship awarded to T.J.P. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2018",

month = apr,

doi = "10.3390/genes9040178",

language = "English",

volume = "9",

journal = "Genes",

issn = "2073-4425",

publisher = "MDPI AG",

number = "4",

}

TY - JOUR

T1 - Wnt signalling in gastrointestinal epithelial stem cells

AU - Flanagan, Dustin J.

AU - Austin, Chloe R.

AU - Vincan, Elizabeth

AU - Phesse, Toby J.

N1 - Funding Information: The authors wish to thank Gavan Mitchell for helping generate the figures in this manuscript. Funding is gratefully acknowledged from the following; National Health and Medical Research Council of Australia (NHMRC) project grants (566679 and APP1099302 awarded to E.V.); Melbourne Health project grants (605030 and PG-002 awarded to E.V./T.J.P.), and an Early Career Researcher grant (GIA-033) awarded to D.J.F.; Cancer Council of Victoria project grants (CCV, APP1020716) awarded to E.V. and T.J.P., CCV Fellowship awarded to D.J.F. and Cardiff University Research Fellowship awarded to T.J.P. Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2018/4

Y1 - 2018/4

N2 - Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is critical for embryonic development. Stem cells are defined by their ability for self-renewal and the ability to be able to give rise to differentiated progeny. Consequently, they are essential for the homeostasis of many organs including the gastrointestinal tract. This review will describe the huge advances in our understanding of how stem cell functions in the gastrointestinal tract are regulated by Wnt signalling, including how deregulated Wnt signalling can hijack these functions to transform cells and lead to cancer.

AB - Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is critical for embryonic development. Stem cells are defined by their ability for self-renewal and the ability to be able to give rise to differentiated progeny. Consequently, they are essential for the homeostasis of many organs including the gastrointestinal tract. This review will describe the huge advances in our understanding of how stem cell functions in the gastrointestinal tract are regulated by Wnt signalling, including how deregulated Wnt signalling can hijack these functions to transform cells and lead to cancer.

KW - Cancer

KW - Epithelium

KW - Gastric

KW - Intestine

KW - Plasticity

KW - Regeneration

KW - Stem cells

KW - Stomach

KW - Wnt signalling

UR - https://www.scopus.com/pages/publications/85044589481

U2 - 10.3390/genes9040178

DO - 10.3390/genes9040178

M3 - Review Article

C2 - 29570681

AN - SCOPUS:85044589481

SN - 2073-4425

VL - 9

JO - Genes

JF - Genes

IS - 4

M1 - 178

ER -

Wnt signalling in gastrointestinal epithelial stem cells

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Cite this