Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer

Theodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker, Elizabeth Vincan

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

The different branches of the Wnt signaling pathway were first characterized in developmental contexts, but in recent times, each branch has been implicated in tumor growth and progression. This chapter exemplifies this link between development and cancer by focusing on two Wnt-driven cancers, colorectal cancer (CRC) and hepatocellular carcinoma (HCC). It focuses on the processes of epithelial-to-mesenchymal transition (EMT) and the reverse transition, mesenchymal-to-epithelial transition (MET), both fundamental mechanisms of tumor metastasis and morphogenesis. HCC shares many parallels with CRC with respect to the involvement of Wnt signaling in cancer initiation and progression.

Original languageEnglish
Title of host publicationWnt Signaling in Development and Disease
Subtitle of host publicationMolecular Mechanisms and Biological Functions
EditorsStefan Hoppler, Randall T. Moon
PublisherWiley-Blackwell
Chapter24
Pages315-328
Number of pages14
ISBN (Electronic)9781118444122
ISBN (Print)9781118444160
DOIs
Publication statusPublished - 12 May 2014
Externally publishedYes

Keywords

  • Colorectal cancer (CRC) morphogenesis
  • Epithelial-to-mesenchymal (EMT) transition
  • Hepatocellular carcinoma (HCC)
  • Mesenchymal-to-epithelial (MET) transition
  • Metastasis
  • Tumor growth
  • Wnt signaling pathways

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