Wnt signaling in cancer: Not a binary on:off switch

Dustin J. Flanagan, Elizabeth Vincan, Toby J. Phesse

Research output: Contribution to journalReview ArticleResearchpeer-review

51 Citations (Scopus)

Abstract

In the March 1 issue of Cancer Research, we identified the Wnt receptor Fzd7 as an attractive therapeutic target for the treatment of gastric cancer. In summary, we showed that pharmacological inhibition of Wnt receptors, or genetic deletion of Fzd7, blocks the initiation and growth of gastric tumors. Inhibiting Fzd receptors, specifically Fzd7, inhibits the growth of gastric cancer cells even in the presence of adenomatous polyposis coli (Apc) mutation. Apc is located in the cytoplasm downstream of Fzd7 in the Wnt signaling cascade and APC mutations activate Wnt/b-catenin signaling, therefore, this result seems counterintuitive. Here, we analyze this result in greater detail in the context of current knowledge of Wnt signaling and discuss the wider implications of this aspect of Wnt signaling in other cancers.

Original languageEnglish
Pages (from-to)5901-5906
Number of pages6
JournalCancer Research
Volume79
Issue number23
DOIs
Publication statusPublished - Dec 2019
Externally publishedYes

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