Within-session repeated a-tDCS: the effects of repetition rate and inter-stimulus interval on corticospinal excitability and motor performance

Andisheh Bastani, Shapour Jaberzadeh

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32 Citations (Scopus)

Abstract

Objective: This study investigated the effect of rate and stimulation interval of anodal transcranial direct current stimulation (a-tDCS) on CSE and motor performance. Methods: Twelve healthy individuals participated in this study. CSE was assessed before and after five experimental conditions of one, two or three applications of 10min of a-tDCS with an interval of 5 or 25min. a-tDCS was applied with a constant current density of 0.016mA/cm2. Purdue pegboard-test was selected for motor performance assessment. Results: Compared to single 10. min stimulation, the magnitude of the within-session repeated a-tDCS induced excitability was enhanced significantly after the second stimulation was performed with an interval of 25. min, but not 5. min. However, by increasing the number of a-tDCS to three repetitions the CSE was significantly increased and lasted for 2. h with both 5 and 25. min intervals. Furthermore, CSE enhancement remained significant for up to 24. h for within session a-tDCS repetitions with 25. min intervals. Likewise, significant improvement was seen in motor performance following three times repetition with 25. min inter-stimulus intervals. Conclusions: The results suggest that within session repeated a-tDCS with longer intervals within the lasting effects of the previous stimulations are preferable for increasing induced excitability changes with longer lasting effects. Significance: It is of particular importance to increase the a-tDCS lasting effects to consolidate the neuroplastic CSE changes
Original languageEnglish
Pages (from-to)1809 - 1818
Number of pages10
JournalClinical Neurophysiology
Volume125
Issue number9
DOIs
Publication statusPublished - 2014

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