Within-host viral dynamics of dengue serotype 1 infection

Hannah E. Clapham, Vianney Tricou, Nguyen Van Vinh Chau, Cameron P. Simmons, Neil M Ferguson

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59 Citations (Scopus)

Abstract

Dengue, the most common mosquito-borne viral infection of humans, is endemic across much of the world, including much of tropical Asia and is increasing in its geographical range. Here, we present a mathematical model of dengue virus dynamics within infected individuals, detailing the interaction between virus and a simple immune response. We fit this model to measurements of plasma viral titre from cases of primary and secondary DENV 1 infection in Vietnam. We show that variation in model parameters governing the immune response is sufficient to create the observed variation in virus dynamics between individuals. Estimating model parameter values, we find parameter differences between primary and secondary cases consistent with the theory of antibody-dependent enhancement (namely enhanced rates of viral entry to target cells in secondary cases). Finally, we use our model to examine the potential impact of an antiviral drug on the within-host dynamics of dengue. We conclude that the impact of antiviral therapy on virus dynamics is likely to be limited if therapy is only started at the onset of symptoms, owing to the typically late stage of viral pathogenesis reached by the time symptoms are manifested and thus treatment is started.

Original languageEnglish
Article number20140094
Number of pages11
JournalJournal of the Royal Society Interface
Volume11
Issue number96
DOIs
Publication statusPublished - 6 Jul 2014
Externally publishedYes

Keywords

  • Dengue
  • Virus dynamics
  • Within-host modelling

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