Williams-Beuren Syndrome and Congenital Lobar Emphysema: Uncommon Association with Common Pathology?

Timothy A. Walsh, Gopagondanahalli Krishna Revanna, Atul Malhotra

Research output: Contribution to journal › Article › Other › peer-review

Abstract

Introduction. Congenital lobar emphysema (CLE) and Williams-Beuren Syndrome are two rare conditions that have only been reported together in a single case study. Case Presentation. We report another case of a male Caucasian newborn with nonspecific initial respiratory distress, with detection of CLE on repeat chest X-ray on Day 25 of life and concurrent ventricular septal defect, supravalvular aortic stenosis, and branch pulmonary stenosis, in whom a 7q11.23 deletion consistent with Williams-Beuren Syndrome was made. Conclusion. A diagnosis of congenital lobar emphysema should prompt further screening for congenital heart disease and genetic deletion, and further research is needed to investigate the role of elastin gene mutation in the development of the neonatal lung.
Original languageEnglish
Article number3480980
Number of pages4
JournalCase Reports in Pediatrics
Volume2017
DOIs
Publication statusPublished - 24 May 2017

Cite this

Walsh, Timothy A. ; Revanna, Gopagondanahalli Krishna ; Malhotra, Atul. / Williams-Beuren Syndrome and Congenital Lobar Emphysema : Uncommon Association with Common Pathology?. In: Case Reports in Pediatrics. 2017 ; Vol. 2017.
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abstract = "Introduction. Congenital lobar emphysema (CLE) and Williams-Beuren Syndrome are two rare conditions that have only been reported together in a single case study. Case Presentation. We report another case of a male Caucasian newborn with nonspecific initial respiratory distress, with detection of CLE on repeat chest X-ray on Day 25 of life and concurrent ventricular septal defect, supravalvular aortic stenosis, and branch pulmonary stenosis, in whom a 7q11.23 deletion consistent with Williams-Beuren Syndrome was made. Conclusion. A diagnosis of congenital lobar emphysema should prompt further screening for congenital heart disease and genetic deletion, and further research is needed to investigate the role of elastin gene mutation in the development of the neonatal lung.",
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Walsh, TA, Revanna, GK & Malhotra, A 2017, 'Williams-Beuren Syndrome and Congenital Lobar Emphysema: Uncommon Association with Common Pathology?', Case Reports in Pediatrics, vol. 2017, 3480980. https://doi.org/10.1155/2017/3480980

Williams-Beuren Syndrome and Congenital Lobar Emphysema : Uncommon Association with Common Pathology? / Walsh, Timothy A.; Revanna, Gopagondanahalli Krishna; Malhotra, Atul.

In: Case Reports in Pediatrics, Vol. 2017, 3480980, 24.05.2017.

Research output: Contribution to journal › Article › Other › peer-review

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T1 - Williams-Beuren Syndrome and Congenital Lobar Emphysema

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AU - Walsh, Timothy A.

AU - Revanna, Gopagondanahalli Krishna

AU - Malhotra, Atul

PY - 2017/5/24

Y1 - 2017/5/24

N2 - Introduction. Congenital lobar emphysema (CLE) and Williams-Beuren Syndrome are two rare conditions that have only been reported together in a single case study. Case Presentation. We report another case of a male Caucasian newborn with nonspecific initial respiratory distress, with detection of CLE on repeat chest X-ray on Day 25 of life and concurrent ventricular septal defect, supravalvular aortic stenosis, and branch pulmonary stenosis, in whom a 7q11.23 deletion consistent with Williams-Beuren Syndrome was made. Conclusion. A diagnosis of congenital lobar emphysema should prompt further screening for congenital heart disease and genetic deletion, and further research is needed to investigate the role of elastin gene mutation in the development of the neonatal lung.

AB - Introduction. Congenital lobar emphysema (CLE) and Williams-Beuren Syndrome are two rare conditions that have only been reported together in a single case study. Case Presentation. We report another case of a male Caucasian newborn with nonspecific initial respiratory distress, with detection of CLE on repeat chest X-ray on Day 25 of life and concurrent ventricular septal defect, supravalvular aortic stenosis, and branch pulmonary stenosis, in whom a 7q11.23 deletion consistent with Williams-Beuren Syndrome was made. Conclusion. A diagnosis of congenital lobar emphysema should prompt further screening for congenital heart disease and genetic deletion, and further research is needed to investigate the role of elastin gene mutation in the development of the neonatal lung.

U2 - 10.1155/2017/3480980

DO - 10.1155/2017/3480980

M3 - Article

VL - 2017

JO - Case Reports in Pediatrics

JF - Case Reports in Pediatrics

SN - 2090-6803

M1 - 3480980

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Walsh TA, Revanna GK, Malhotra A. Williams-Beuren Syndrome and Congenital Lobar Emphysema: Uncommon Association with Common Pathology? Case Reports in Pediatrics. 2017 May 24;2017. 3480980. https://doi.org/10.1155/2017/3480980

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