TY - JOUR
T1 - Will acarbose improve the metabolic abnormalities of insulin-resistant type 2 diabetes mellitus?
AU - Scott, R.
AU - Lintott, C. J.
AU - Zimmet, P.
AU - Campbell, L.
AU - Bowen, K.
AU - Welborn, T.
PY - 1999/3
Y1 - 1999/3
N2 - Individuals with type 2 diabetes mellitus (n = 105; age 36-71 years) on diet therapy alone, and with quite good glycaemic control (mean HbA(1c) ≃ 7 0%) were randomized to receive acarbose (100 mg three times daily) or placebo for 16 weeks, and changes in clinical and metabolic parameters indicative of Syndrome X were monitored. Fasting levels of glucose, glycosylated haemoglobin (HbA(1c)), true insulin, proinsulin, fibrinogen and lipids were measured four times weekly, and glucose, insulin, proinsulin and triglyceride responses to a standardized 1.6 MJ breakfast were determined at 0, 1 and 2 h post meal. Analysis was on an intention-to-treat basis. Fasting levels of glucose (P < 0.0001), triglycerides (P = 0.03) and Hb(1c) (P = 0.003) were reduced by acarbose over the 16 weeks of treatment. The mean change in HbA(1c) from week 0 to 16 differed by 0.4% (P=0.003) between the two groups. Insulin (P = 0.06), proinsulin (P = 0.07) and glucose (P < 0.0001) responses to the standard meal were reduced. These data show that acarbose reduces fasting glucose and triglyceride levels, lowers HbA(1c) and limits the glycaemic and insulin response to food in individuals with type 2 diabetes mellitus with Syndrome X. Pharmacological agents that improve the metabolic environment and reduce insulin resistance have the potential to limit the progression of atherogenesis associated with type 2 diabetes mellitus.
AB - Individuals with type 2 diabetes mellitus (n = 105; age 36-71 years) on diet therapy alone, and with quite good glycaemic control (mean HbA(1c) ≃ 7 0%) were randomized to receive acarbose (100 mg three times daily) or placebo for 16 weeks, and changes in clinical and metabolic parameters indicative of Syndrome X were monitored. Fasting levels of glucose, glycosylated haemoglobin (HbA(1c)), true insulin, proinsulin, fibrinogen and lipids were measured four times weekly, and glucose, insulin, proinsulin and triglyceride responses to a standardized 1.6 MJ breakfast were determined at 0, 1 and 2 h post meal. Analysis was on an intention-to-treat basis. Fasting levels of glucose (P < 0.0001), triglycerides (P = 0.03) and Hb(1c) (P = 0.003) were reduced by acarbose over the 16 weeks of treatment. The mean change in HbA(1c) from week 0 to 16 differed by 0.4% (P=0.003) between the two groups. Insulin (P = 0.06), proinsulin (P = 0.07) and glucose (P < 0.0001) responses to the standard meal were reduced. These data show that acarbose reduces fasting glucose and triglyceride levels, lowers HbA(1c) and limits the glycaemic and insulin response to food in individuals with type 2 diabetes mellitus with Syndrome X. Pharmacological agents that improve the metabolic environment and reduce insulin resistance have the potential to limit the progression of atherogenesis associated with type 2 diabetes mellitus.
KW - Acarbose
KW - Syndrome X
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0032959409&partnerID=8YFLogxK
U2 - 10.1016/S0168-8227(99)00009-1
DO - 10.1016/S0168-8227(99)00009-1
M3 - Article
C2 - 10369427
AN - SCOPUS:0032959409
SN - 0168-8227
VL - 43
SP - 179
EP - 185
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -