Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response

Melissa J. Bell, Rebekah Brennan, John J. Miles, Denis J. Moss, Jacqueline M. Burrows, Scott R. Burrows

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome and its expression in all EBV-associated malignancies. Much of this research has focused exclusively on the EBV wild-type (wt) strain (B95-8). Sequence analysis of the gene encoding for EBNA1 in EBV isolates from 43 Caucasians has now revealed considerable EBNA1 sequence divergence from the EBV wt strain in the majority of isolates from this population group. Importantly, T cell recognition of an endogenously processed HLA-B8 - binding EBNA1 epitope was greatly influenced by this sequence polymorphism.

Original languageEnglish
Pages (from-to)1594-1597
Number of pages4
JournalJournal of Infectious Diseases
Volume197
Issue number11
DOIs
Publication statusPublished - 1 Jun 2008
Externally publishedYes

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