Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response

Melissa J. Bell; Rebekah Brennan; John J. Miles; Denis J. Moss; Jacqueline M. Burrows; Scott R. Burrows

doi:10.1086/587848

Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response

Melissa J. Bell, Rebekah Brennan, John J. Miles, Denis J. Moss, Jacqueline M. Burrows, Scott R. Burrows

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome and its expression in all EBV-associated malignancies. Much of this research has focused exclusively on the EBV wild-type (wt) strain (B95-8). Sequence analysis of the gene encoding for EBNA1 in EBV isolates from 43 Caucasians has now revealed considerable EBNA1 sequence divergence from the EBV wt strain in the majority of isolates from this population group. Importantly, T cell recognition of an endogenously processed HLA-B8 - binding EBNA1 epitope was greatly influenced by this sequence polymorphism.

Original language	English
Pages (from-to)	1594-1597
Number of pages	4
Journal	The Journal of Infectious Diseases
Volume	197
Issue number	11
DOIs	https://doi.org/10.1086/587848
Publication status	Published - 1 Jun 2008
Externally published	Yes

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abstract = "Epstein-Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome and its expression in all EBV-associated malignancies. Much of this research has focused exclusively on the EBV wild-type (wt) strain (B95-8). Sequence analysis of the gene encoding for EBNA1 in EBV isolates from 43 Caucasians has now revealed considerable EBNA1 sequence divergence from the EBV wt strain in the majority of isolates from this population group. Importantly, T cell recognition of an endogenously processed HLA-B8 - binding EBNA1 epitope was greatly influenced by this sequence polymorphism.",

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AU - Miles, John J.

AU - Moss, Denis J.

AU - Burrows, Jacqueline M.

AU - Burrows, Scott R.

PY - 2008/6/1

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N2 - Epstein-Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome and its expression in all EBV-associated malignancies. Much of this research has focused exclusively on the EBV wild-type (wt) strain (B95-8). Sequence analysis of the gene encoding for EBNA1 in EBV isolates from 43 Caucasians has now revealed considerable EBNA1 sequence divergence from the EBV wt strain in the majority of isolates from this population group. Importantly, T cell recognition of an endogenously processed HLA-B8 - binding EBNA1 epitope was greatly influenced by this sequence polymorphism.

AB - Epstein-Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome and its expression in all EBV-associated malignancies. Much of this research has focused exclusively on the EBV wild-type (wt) strain (B95-8). Sequence analysis of the gene encoding for EBNA1 in EBV isolates from 43 Caucasians has now revealed considerable EBNA1 sequence divergence from the EBV wt strain in the majority of isolates from this population group. Importantly, T cell recognition of an endogenously processed HLA-B8 - binding EBNA1 epitope was greatly influenced by this sequence polymorphism.

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JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

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ER -

Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response

Abstract

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