TY - JOUR
T1 - Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers
AU - Leroueil, Pascale R.
AU - Berry, Stephanie A.
AU - Duthie, Kristen
AU - Han, Gang
AU - Rotello, Vincent M.
AU - McNerny, Daniel Q.
AU - Baker, James R.
AU - Orr, Bradford G.
AU - Holl, Mark M Banaszak
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or thinned regions, is a common mechanism of interaction between these nanoparticles and lipids. It was found that a wide variety of nanoparticles, including a cell penetrating pepide (MSI-78), a protein (TAT), polycationic polymers (PAMAM dendrimers, pentanol-core PAMAM dendrons, polyethyleneimine, and diethylaminoethyl-dextran), and two inorganic particles (Au-NH 2, SiO 2-NH 2), can induce disruption, including the formation of holes, membrane thinning, and/or membrane erosion, in supported lipid bilayers.
AB - Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or thinned regions, is a common mechanism of interaction between these nanoparticles and lipids. It was found that a wide variety of nanoparticles, including a cell penetrating pepide (MSI-78), a protein (TAT), polycationic polymers (PAMAM dendrimers, pentanol-core PAMAM dendrons, polyethyleneimine, and diethylaminoethyl-dextran), and two inorganic particles (Au-NH 2, SiO 2-NH 2), can induce disruption, including the formation of holes, membrane thinning, and/or membrane erosion, in supported lipid bilayers.
UR - https://www.scopus.com/pages/publications/40449123201
U2 - 10.1021/nl0722929
DO - 10.1021/nl0722929
M3 - Article
C2 - 18217783
AN - SCOPUS:40449123201
SN - 1530-6984
VL - 8
SP - 420
EP - 424
JO - Nano Letters
JF - Nano Letters
IS - 2
ER -