Why Do the Fetal Membranes Rupture Early after Fetoscopy? A Review

Benjamin J. Amberg; Ryan J. Hodges; Karyn A. Rodgers; Kelly J. Crossley; Stuart B. Hooper; Philip L.J. Dekoninck

doi:10.1159/000517151

Why Do the Fetal Membranes Rupture Early after Fetoscopy? A Review

Benjamin J. Amberg, Ryan J. Hodges, Karyn A. Rodgers, Kelly J. Crossley, Stuart B. Hooper, Philip L.J. Dekoninck

Obstetrics & Gynaecology Monash Health

Research output: Contribution to journal › Review Article › Research › peer-review

17 Citations (Scopus)

Abstract

Iatrogenic preterm premature rupture of the fetal membranes (iPPROM) remains the Achilles' heel of keyhole fetal surgery (fetoscopy) despite significant efforts in preclinical models to develop new therapies. This limited success is partially due to incomplete understanding why the fetal membranes rupture early after fetoscopy and notable differences in membrane physiology between humans and domestic species. In this review, we summarize aspects of fetoscopy that may contribute to iPPROM, the previous efforts to develop new therapies, and limitations of preclinical models commonly used in fetal membrane research.

Original language	English
Pages (from-to)	493-503
Number of pages	11
Journal	Fetal Diagnosis and Therapy
Volume	48
Issue number	7
DOIs	https://doi.org/10.1159/000517151
Publication status	Published - Sept 2021

Keywords

Amnion
Chorion
Fetoscopy
Iatrogenic preterm premature rupture of membranes
Matrix metalloprotease
Preclinical model

Access to Document

10.1159/000517151Licence: CC BY-NC

Cite this

@article{ebac55b5aee64be1a2b1928da8cd85b1,

title = "Why Do the Fetal Membranes Rupture Early after Fetoscopy? A Review",

abstract = "Iatrogenic preterm premature rupture of the fetal membranes (iPPROM) remains the Achilles' heel of keyhole fetal surgery (fetoscopy) despite significant efforts in preclinical models to develop new therapies. This limited success is partially due to incomplete understanding why the fetal membranes rupture early after fetoscopy and notable differences in membrane physiology between humans and domestic species. In this review, we summarize aspects of fetoscopy that may contribute to iPPROM, the previous efforts to develop new therapies, and limitations of preclinical models commonly used in fetal membrane research. ",

keywords = "Amnion, Chorion, Fetoscopy, Iatrogenic preterm premature rupture of membranes, Matrix metalloprotease, Preclinical model",

author = "Amberg, {Benjamin J.} and Hodges, {Ryan J.} and Rodgers, {Karyn A.} and Crossley, {Kelly J.} and Hooper, {Stuart B.} and Dekoninck, {Philip L.J.}",

note = "Funding Information: This research was supported by an Australian Government Research Training Program Scholarship awarded to Benjamin Amberg at Monash University with Award number 25129015. Publisher Copyright: {\textcopyright} 2021 The Author(s) Published by S. Karger AG, Basel.",

year = "2021",

month = sep,

doi = "10.1159/000517151",

language = "English",

volume = "48",

pages = "493--503",

journal = "Fetal Diagnosis and Therapy",

issn = "1015-3837",

publisher = "S Karger AG",

number = "7",

}

TY - JOUR

T1 - Why Do the Fetal Membranes Rupture Early after Fetoscopy? A Review

AU - Amberg, Benjamin J.

AU - Hodges, Ryan J.

AU - Rodgers, Karyn A.

AU - Crossley, Kelly J.

AU - Hooper, Stuart B.

AU - Dekoninck, Philip L.J.

N1 - Funding Information: This research was supported by an Australian Government Research Training Program Scholarship awarded to Benjamin Amberg at Monash University with Award number 25129015. Publisher Copyright: © 2021 The Author(s) Published by S. Karger AG, Basel.

PY - 2021/9

Y1 - 2021/9

N2 - Iatrogenic preterm premature rupture of the fetal membranes (iPPROM) remains the Achilles' heel of keyhole fetal surgery (fetoscopy) despite significant efforts in preclinical models to develop new therapies. This limited success is partially due to incomplete understanding why the fetal membranes rupture early after fetoscopy and notable differences in membrane physiology between humans and domestic species. In this review, we summarize aspects of fetoscopy that may contribute to iPPROM, the previous efforts to develop new therapies, and limitations of preclinical models commonly used in fetal membrane research.

AB - Iatrogenic preterm premature rupture of the fetal membranes (iPPROM) remains the Achilles' heel of keyhole fetal surgery (fetoscopy) despite significant efforts in preclinical models to develop new therapies. This limited success is partially due to incomplete understanding why the fetal membranes rupture early after fetoscopy and notable differences in membrane physiology between humans and domestic species. In this review, we summarize aspects of fetoscopy that may contribute to iPPROM, the previous efforts to develop new therapies, and limitations of preclinical models commonly used in fetal membrane research.

KW - Amnion

KW - Chorion

KW - Fetoscopy

KW - Iatrogenic preterm premature rupture of membranes

KW - Matrix metalloprotease

KW - Preclinical model

UR - http://www.scopus.com/inward/record.url?scp=85113875580&partnerID=8YFLogxK

U2 - 10.1159/000517151

DO - 10.1159/000517151

M3 - Review Article

C2 - 34404043

AN - SCOPUS:85113875580

SN - 1015-3837

VL - 48

SP - 493

EP - 503

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

IS - 7

ER -

Why Do the Fetal Membranes Rupture Early after Fetoscopy? A Review

Abstract

Keywords

Access to Document

Other files and links

Cite this