White matter microstructure in patients with obsessive-compulsive disorder

Emre Bora; Ben J Harrison; Alex Fornito; Luca Cocchi; Jesus M Pujol; Leonardo F Fontenelle; Dennis Velakoulis; Christos Pantelis; Murat Yucel

doi:10.1503/jpn.100082

White matter microstructure in patients with obsessive-compulsive disorder

Emre Bora, Ben J Harrison, Alex Fornito, Luca Cocchi, Jesus M Pujol, Leonardo F Fontenelle, Dennis Velakoulis, Christos Pantelis, Murat Yucel

Research output: Contribution to journal › Article › Research › peer-review

55 Citations (Scopus)

Abstract

Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive?compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.

Original language	English
Pages (from-to)	42-46
Number of pages	5
Journal	Journal of Psychiatry & Neuroscience
Volume	36
Issue number	1
DOIs	https://doi.org/10.1503/jpn.100082
Publication status	Published - 2011
Externally published	Yes

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Cite this

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title = "White matter microstructure in patients with obsessive-compulsive disorder",

abstract = "Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive?compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.",

author = "Emre Bora and Harrison, {Ben J} and Alex Fornito and Luca Cocchi and Pujol, {Jesus M} and Fontenelle, {Leonardo F} and Dennis Velakoulis and Christos Pantelis and Murat Yucel",

year = "2011",

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journal = "Journal of Psychiatry & Neuroscience",

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White matter microstructure in patients with obsessive-compulsive disorder. / Bora, Emre; Harrison, Ben J; Fornito, Alex; Cocchi, Luca; Pujol, Jesus M; Fontenelle, Leonardo F; Velakoulis, Dennis; Pantelis, Christos; Yucel, Murat.

In: Journal of Psychiatry & Neuroscience, Vol. 36, No. 1, 2011, p. 42-46.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - White matter microstructure in patients with obsessive-compulsive disorder

AU - Bora, Emre

AU - Harrison, Ben J

AU - Fornito, Alex

AU - Cocchi, Luca

AU - Pujol, Jesus M

AU - Fontenelle, Leonardo F

AU - Velakoulis, Dennis

AU - Pantelis, Christos

AU - Yucel, Murat

PY - 2011

Y1 - 2011

N2 - Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive?compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.

AB - Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive?compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.

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DO - 10.1503/jpn.100082

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JO - Journal of Psychiatry & Neuroscience

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