White matter microstructure in opiate addiction

Emre Bora, Murat Yucel, Alex Fornito, Christos Pantelis, Ben J Harrison, Luca Cocchi, Gaby Pell, Dan Lubman

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)


Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially explains these findings is alterations in white matter connectivity secondary to chronic opiate use. However, few studies have quantitavely examined white matter deficits in opiate addiction (OA). Here, we investigated white matter microstructure in OA using diffusion tensor imaging (DTI). We performed voxel-wise analysis of fractional anisotropy (FA) in 24 participants with OA and 29 healthy controls. The OA group showed reduced FA in multiple pathways including the corpus callosum, thalamic radiation and inferior longitudinal fasciculus. This FA reduction was mainly the result of increased radial diffusivity (??), indicative of myelin pathology. Longer duration of OA was also associated with axonal diffusivity (?1), most robustly in superior longitudinal fasciculi and right frontal white matter suggesting axonal injury in long-term users. Together, the findings indicate that chronic OA use has widespread and diverse effects on neuronal connectivity and function.
Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalAddiction Biology
Issue number1
Publication statusPublished - Jan 2012


  • corpus callosum
  • DTI
  • heroin
  • MRI
  • opiate
  • white matter

Cite this