White matter lesion progression: genome-wide search for genetic influences

Edith Hofer; Margherita Cavalieri; Joshua C Bis; Charles S DeCarli; Myriam Fornage; Sigurdur Sigurdsson; Velandai Srikanth; Stella Trompet; Benjamin F J Verhaaren; Christiane Wolf; Qiong Yang; Hieab H H Adams; Philippe Amouyel; Alexa Beiser; Brendan M Buckley; Michele Callisaya; Ganesh Chauhan; Anton J M de Craen; Carole Dufouil; Cornelia M van Duijn; Ian Ford; Paul Freudenberger; Rebecca F Gottesman; Vilmundur G Gudnason; Gerardo Heiss; Albert Hofman; Thomas S Lumley; Oliver O Martinez; Bernard Mazoyer; Christopher Moran; Wiro J Niessen; Thanh G Phan; Bruce M Psaty; Claudia Liliana Satizabal; Naveed A Sattar; Sabrina Schilling; Dean K Shibata; Pieternella Eline Slagboom; Albert Vernon Smith; David J Stott; Kent D Taylor; Russell Thomson; Anna Maria Toglhofer; Christophe Tzourio; Mark A van Buchem; Jing Wang; Rudi G J Westendorp; Beverly Gwen Windham; Meike W Vernooij; Alex P Zijdenbos; Richard Beare; Stephanie Debette; Mohammed Arfan Ikram; J Wouter Jukema; Lenore J Launer; William T Longstreth Jr; Thomas H Mosley; Sudha Seshadri; Helena Schmidt; Reinhold Schmidt

doi:10.1161/STROKEAHA.115.009252

White matter lesion progression: genome-wide search for genetic influences

Edith Hofer, Margherita Cavalieri, Joshua C Bis, Charles S DeCarli, Myriam Fornage, Sigurdur Sigurdsson, Velandai Srikanth, Stella Trompet, Benjamin F J Verhaaren, Christiane Wolf, Qiong Yang, Hieab H H Adams, Philippe Amouyel, Alexa Beiser, Brendan M Buckley, Michele Callisaya, Ganesh Chauhan, Anton J M de Craen, Carole Dufouil, Cornelia M van DuijnIan Ford, Paul Freudenberger, Rebecca F Gottesman, Vilmundur G Gudnason, Gerardo Heiss, Albert Hofman, Thomas S Lumley, Oliver O Martinez, Bernard Mazoyer, Christopher Moran, Wiro J Niessen, Thanh G Phan, Bruce M Psaty, Claudia Liliana Satizabal, Naveed A Sattar, Sabrina Schilling, Dean K Shibata, Pieternella Eline Slagboom, Albert Vernon Smith, David J Stott, Kent D Taylor, Russell Thomson, Anna Maria Toglhofer, Christophe Tzourio, Mark A van Buchem, Jing Wang, Rudi G J Westendorp, Beverly Gwen Windham, Meike W Vernooij, Alex P Zijdenbos, Richard Beare, Stephanie Debette, Mohammed Arfan Ikram, J Wouter Jukema, Lenore J Launer, William T Longstreth Jr, Thomas H Mosley, Sudha Seshadri, Helena Schmidt, Reinhold Schmidt

Medicine Monash Health

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. METHODS: Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-nucleotide polymorphisms that have been shown to be associated cross-sectionally with WML in the current and previous association studies. RESULTS: A total of 1085 subjects showed WML progression. The heritability estimate for WML progression was low at 6.5 , and no single-nucleotide polymorphisms achieved genome-wide significance (P

Original language	English
Pages (from-to)	3048 - 3057
Number of pages	10
Journal	Stroke
Volume	46
Issue number	11
DOIs	https://doi.org/10.1161/STROKEAHA.115.009252
Publication status	Published - 2015

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10.1161/STROKEAHA.115.009252

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Hofer, E., Cavalieri, M., Bis, J. C., DeCarli, C. S., Fornage, M., Sigurdsson, S., Srikanth, V., Trompet, S., Verhaaren, B. F. J., Wolf, C., Yang, Q., Adams, H. H. H., Amouyel, P., Beiser, A., Buckley, B. M., Callisaya, M., Chauhan, G., de Craen, A. J. M., Dufouil, C., ... Schmidt, R. (2015). White matter lesion progression: genome-wide search for genetic influences. Stroke, 46(11), 3048 - 3057. https://doi.org/10.1161/STROKEAHA.115.009252

@article{e7d3e43e6a2649e8ab0e6f64759e2fe4,

title = "White matter lesion progression: genome-wide search for genetic influences",

abstract = "BACKGROUND AND PURPOSE: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. METHODS: Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-nucleotide polymorphisms that have been shown to be associated cross-sectionally with WML in the current and previous association studies. RESULTS: A total of 1085 subjects showed WML progression. The heritability estimate for WML progression was low at 6.5 , and no single-nucleotide polymorphisms achieved genome-wide significance (P",

author = "Edith Hofer and Margherita Cavalieri and Bis, {Joshua C} and DeCarli, {Charles S} and Myriam Fornage and Sigurdur Sigurdsson and Velandai Srikanth and Stella Trompet and Verhaaren, {Benjamin F J} and Christiane Wolf and Qiong Yang and Adams, {Hieab H H} and Philippe Amouyel and Alexa Beiser and Buckley, {Brendan M} and Michele Callisaya and Ganesh Chauhan and {de Craen}, {Anton J M} and Carole Dufouil and {van Duijn}, {Cornelia M} and Ian Ford and Paul Freudenberger and Gottesman, {Rebecca F} and Gudnason, {Vilmundur G} and Gerardo Heiss and Albert Hofman and Lumley, {Thomas S} and Martinez, {Oliver O} and Bernard Mazoyer and Christopher Moran and Niessen, {Wiro J} and Phan, {Thanh G} and Psaty, {Bruce M} and Satizabal, {Claudia Liliana} and Sattar, {Naveed A} and Sabrina Schilling and Shibata, {Dean K} and Slagboom, {Pieternella Eline} and Smith, {Albert Vernon} and Stott, {David J} and Taylor, {Kent D} and Russell Thomson and Toglhofer, {Anna Maria} and Christophe Tzourio and {van Buchem}, {Mark A} and Jing Wang and Westendorp, {Rudi G J} and Windham, {Beverly Gwen} and Vernooij, {Meike W} and Zijdenbos, {Alex P} and Richard Beare and Stephanie Debette and Ikram, {Mohammed Arfan} and Jukema, {J Wouter} and Launer, {Lenore J} and {Longstreth Jr}, {William T} and Mosley, {Thomas H} and Sudha Seshadri and Helena Schmidt and Reinhold Schmidt",

year = "2015",

doi = "10.1161/STROKEAHA.115.009252",

language = "English",

volume = "46",

pages = "3048 -- 3057",

journal = "Stroke",

issn = "0039-2499",

publisher = "American Heart Association",

number = "11",

}

Hofer, E, Cavalieri, M, Bis, JC, DeCarli, CS, Fornage, M, Sigurdsson, S, Srikanth, V, Trompet, S, Verhaaren, BFJ, Wolf, C, Yang, Q, Adams, HHH, Amouyel, P, Beiser, A, Buckley, BM, Callisaya, M, Chauhan, G, de Craen, AJM, Dufouil, C, van Duijn, CM, Ford, I, Freudenberger, P, Gottesman, RF, Gudnason, VG, Heiss, G, Hofman, A, Lumley, TS, Martinez, OO, Mazoyer, B, Moran, C, Niessen, WJ, Phan, TG, Psaty, BM, Satizabal, CL, Sattar, NA, Schilling, S, Shibata, DK, Slagboom, PE, Smith, AV, Stott, DJ, Taylor, KD, Thomson, R, Toglhofer, AM, Tzourio, C, van Buchem, MA, Wang, J, Westendorp, RGJ, Windham, BG, Vernooij, MW, Zijdenbos, AP, Beare, R, Debette, S, Ikram, MA, Jukema, JW, Launer, LJ, Longstreth Jr, WT, Mosley, TH, Seshadri, S, Schmidt, H & Schmidt, R 2015, 'White matter lesion progression: genome-wide search for genetic influences', Stroke, vol. 46, no. 11, pp. 3048 - 3057. https://doi.org/10.1161/STROKEAHA.115.009252

TY - JOUR

T1 - White matter lesion progression: genome-wide search for genetic influences

AU - Hofer, Edith

AU - Cavalieri, Margherita

AU - Bis, Joshua C

AU - DeCarli, Charles S

AU - Fornage, Myriam

AU - Sigurdsson, Sigurdur

AU - Srikanth, Velandai

AU - Trompet, Stella

AU - Verhaaren, Benjamin F J

AU - Wolf, Christiane

AU - Yang, Qiong

AU - Adams, Hieab H H

AU - Amouyel, Philippe

AU - Beiser, Alexa

AU - Buckley, Brendan M

AU - Callisaya, Michele

AU - Chauhan, Ganesh

AU - de Craen, Anton J M

AU - Dufouil, Carole

AU - van Duijn, Cornelia M

AU - Ford, Ian

AU - Freudenberger, Paul

AU - Gottesman, Rebecca F

AU - Gudnason, Vilmundur G

AU - Heiss, Gerardo

AU - Hofman, Albert

AU - Lumley, Thomas S

AU - Martinez, Oliver O

AU - Mazoyer, Bernard

AU - Moran, Christopher

AU - Niessen, Wiro J

AU - Phan, Thanh G

AU - Psaty, Bruce M

AU - Satizabal, Claudia Liliana

AU - Sattar, Naveed A

AU - Schilling, Sabrina

AU - Shibata, Dean K

AU - Slagboom, Pieternella Eline

AU - Smith, Albert Vernon

AU - Stott, David J

AU - Taylor, Kent D

AU - Thomson, Russell

AU - Toglhofer, Anna Maria

AU - Tzourio, Christophe

AU - van Buchem, Mark A

AU - Wang, Jing

AU - Westendorp, Rudi G J

AU - Windham, Beverly Gwen

AU - Vernooij, Meike W

AU - Zijdenbos, Alex P

AU - Beare, Richard

AU - Debette, Stephanie

AU - Ikram, Mohammed Arfan

AU - Jukema, J Wouter

AU - Launer, Lenore J

AU - Longstreth Jr, William T

AU - Mosley, Thomas H

AU - Seshadri, Sudha

AU - Schmidt, Helena

AU - Schmidt, Reinhold

PY - 2015

Y1 - 2015

N2 - BACKGROUND AND PURPOSE: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. METHODS: Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-nucleotide polymorphisms that have been shown to be associated cross-sectionally with WML in the current and previous association studies. RESULTS: A total of 1085 subjects showed WML progression. The heritability estimate for WML progression was low at 6.5 , and no single-nucleotide polymorphisms achieved genome-wide significance (P

AB - BACKGROUND AND PURPOSE: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. METHODS: Heritability of WML progression was calculated in the Framingham Heart Study. The genome-wide association study included 7773 elderly participants from 10 cohorts. To assess the relative contribution of genetic factors to progression of WML, we compared in 7 cohorts risk models including demographics, vascular risk factors plus single-nucleotide polymorphisms that have been shown to be associated cross-sectionally with WML in the current and previous association studies. RESULTS: A total of 1085 subjects showed WML progression. The heritability estimate for WML progression was low at 6.5 , and no single-nucleotide polymorphisms achieved genome-wide significance (P

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749149/pdf/nihms-757019.pdf

U2 - 10.1161/STROKEAHA.115.009252

DO - 10.1161/STROKEAHA.115.009252

M3 - Article

SN - 0039-2499

VL - 46

SP - 3048

EP - 3057

JO - Stroke

JF - Stroke

IS - 11

ER -

White matter lesion progression: genome-wide search for genetic influences

Abstract

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