White matter connectivity reflects clinical and cognitive status in Huntington's disease

Govinda Poudel; Julie C Stout; Juan F Dominguez; Louisa Salmon; Andrew J Churchyard; Phyllis Chua; Nellie Georgiou-Karistianis; Gary Francis Egan

doi:10.1016/j.nbd.2014.01.013

White matter connectivity reflects clinical and cognitive status in Huntington's disease

Govinda Poudel, Julie C Stout, Juan F Dominguez, Louisa Salmon, Andrew J Churchyard, Phyllis Chua, Nellie Georgiou-Karistianis, Gary Francis Egan

School of Psychological Sciences

Research output: Contribution to journal › Article › Research › peer-review

58 Citations (Scopus)

Abstract

To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington s disease. Method: Diffusion tensor imaging (DTI) data were acquired from 35 pre-HD, 36 symp-HD, and 35 controls. Structural connectivity was mapped between 40 brain regions of interest using tractography. Between-group differences in structural connectivity were identified using network based statistics. Radial diffusivity (RD) and fractional anisotropy (FA) were compared in the white matter tracts from aberrant networks. RD values in aberrant tracts were correlated with clinical severity, and cognitive and motor performance.

Original language	English
Pages (from-to)	180 - 187
Number of pages	8
Journal	Neurobiology of Disease
Volume	65
DOIs	https://doi.org/10.1016/j.nbd.2014.01.013
Publication status	Published - 2014

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Poudel, G., Stout, J. C., Dominguez, J. F., Salmon, L., Churchyard, A. J., Chua, P., Georgiou-Karistianis, N., & Egan, G. F. (2014). White matter connectivity reflects clinical and cognitive status in Huntington's disease. Neurobiology of Disease, 65, 180 - 187. https://doi.org/10.1016/j.nbd.2014.01.013

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abstract = "To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington s disease. Method: Diffusion tensor imaging (DTI) data were acquired from 35 pre-HD, 36 symp-HD, and 35 controls. Structural connectivity was mapped between 40 brain regions of interest using tractography. Between-group differences in structural connectivity were identified using network based statistics. Radial diffusivity (RD) and fractional anisotropy (FA) were compared in the white matter tracts from aberrant networks. RD values in aberrant tracts were correlated with clinical severity, and cognitive and motor performance.",

author = "Govinda Poudel and Stout, {Julie C} and Dominguez, {Juan F} and Louisa Salmon and Churchyard, {Andrew J} and Phyllis Chua and Nellie Georgiou-Karistianis and Egan, {Gary Francis}",

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doi = "10.1016/j.nbd.2014.01.013",

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White matter connectivity reflects clinical and cognitive status in Huntington's disease. / Poudel, Govinda; Stout, Julie C; Dominguez, Juan F; Salmon, Louisa; Churchyard, Andrew J; Chua, Phyllis ; Georgiou-Karistianis, Nellie ; Egan, Gary Francis.

In: Neurobiology of Disease, Vol. 65, 2014, p. 180 - 187.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

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AU - Poudel, Govinda

AU - Stout, Julie C

AU - Dominguez, Juan F

AU - Salmon, Louisa

AU - Churchyard, Andrew J

AU - Chua, Phyllis

AU - Georgiou-Karistianis, Nellie

AU - Egan, Gary Francis

PY - 2014

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N2 - To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington s disease. Method: Diffusion tensor imaging (DTI) data were acquired from 35 pre-HD, 36 symp-HD, and 35 controls. Structural connectivity was mapped between 40 brain regions of interest using tractography. Between-group differences in structural connectivity were identified using network based statistics. Radial diffusivity (RD) and fractional anisotropy (FA) were compared in the white matter tracts from aberrant networks. RD values in aberrant tracts were correlated with clinical severity, and cognitive and motor performance.

AB - To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington s disease. Method: Diffusion tensor imaging (DTI) data were acquired from 35 pre-HD, 36 symp-HD, and 35 controls. Structural connectivity was mapped between 40 brain regions of interest using tractography. Between-group differences in structural connectivity were identified using network based statistics. Radial diffusivity (RD) and fractional anisotropy (FA) were compared in the white matter tracts from aberrant networks. RD values in aberrant tracts were correlated with clinical severity, and cognitive and motor performance.

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