TY - JOUR
T1 - White matter connectivity reflects clinical and cognitive status in Huntington's disease
AU - Poudel, Govinda
AU - Stout, Julie C
AU - Dominguez, Juan F
AU - Salmon, Louisa
AU - Churchyard, Andrew J
AU - Chua, Phyllis
AU - Georgiou-Karistianis, Nellie
AU - Egan, Gary Francis
PY - 2014
Y1 - 2014
N2 - To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington s disease. Method: Diffusion tensor imaging (DTI) data were acquired from 35 pre-HD, 36 symp-HD, and 35 controls. Structural connectivity was mapped between 40 brain regions of interest using tractography. Between-group differences in structural connectivity were identified using network based statistics. Radial diffusivity (RD) and fractional anisotropy (FA) were compared in the white matter tracts from aberrant networks. RD values in aberrant tracts were correlated with clinical severity, and cognitive and motor performance.
AB - To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington s disease. Method: Diffusion tensor imaging (DTI) data were acquired from 35 pre-HD, 36 symp-HD, and 35 controls. Structural connectivity was mapped between 40 brain regions of interest using tractography. Between-group differences in structural connectivity were identified using network based statistics. Radial diffusivity (RD) and fractional anisotropy (FA) were compared in the white matter tracts from aberrant networks. RD values in aberrant tracts were correlated with clinical severity, and cognitive and motor performance.
UR - http://www.sciencedirect.com/science/article/pii/S0969996114000278
U2 - 10.1016/j.nbd.2014.01.013
DO - 10.1016/j.nbd.2014.01.013
M3 - Article
SN - 0969-9961
VL - 65
SP - 180
EP - 187
JO - Neurobiology of Disease
JF - Neurobiology of Disease
ER -