White matter connectivity reflects clinical and cognitive status in Huntington's disease

Govinda Poudel, Julie C Stout, Juan F Dominguez, Louisa Salmon, Andrew J Churchyard, Phyllis Chua, Nellie Georgiou-Karistianis, Gary Francis Egan

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Abstract

To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington s disease. Method: Diffusion tensor imaging (DTI) data were acquired from 35 pre-HD, 36 symp-HD, and 35 controls. Structural connectivity was mapped between 40 brain regions of interest using tractography. Between-group differences in structural connectivity were identified using network based statistics. Radial diffusivity (RD) and fractional anisotropy (FA) were compared in the white matter tracts from aberrant networks. RD values in aberrant tracts were correlated with clinical severity, and cognitive and motor performance.
Original languageEnglish
Pages (from-to)180 - 187
Number of pages8
JournalNeurobiology of Disease
Volume65
DOIs
Publication statusPublished - 2014

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