TY - JOUR
T1 - White adipocytes: More than just fat depots
AU - Henry, Sarah L
AU - Bensley, Jonathan G
AU - Wood-Bradley, Ryan J
AU - Cullen-McEwen, Luise A
AU - Bertram, John F
AU - Armitage, James A
PY - 2012
Y1 - 2012
N2 - Globally 30 of adults are overweight or obese. The white adipocyte is a major component of adipose tissue, and as the obesity epidemic increases it is critically important to understand the factors determining adipocyte development and function. Adipogenesis has two distinct phases; determination of the adipocyte from a multipotent stem cell, and terminal differentiation of a pre-adipocyte into a mature adipocyte. The environment encountered in early life can alter adipocyte number and size and potentially impact upon adipocyte endocrine function in adulthood. These alterations may contribute to the pathophysiology of chronic diseases and thus targeted therapy of the adipocyte has great potential for treating the current obesity epidemic.
AB - Globally 30 of adults are overweight or obese. The white adipocyte is a major component of adipose tissue, and as the obesity epidemic increases it is critically important to understand the factors determining adipocyte development and function. Adipogenesis has two distinct phases; determination of the adipocyte from a multipotent stem cell, and terminal differentiation of a pre-adipocyte into a mature adipocyte. The environment encountered in early life can alter adipocyte number and size and potentially impact upon adipocyte endocrine function in adulthood. These alterations may contribute to the pathophysiology of chronic diseases and thus targeted therapy of the adipocyte has great potential for treating the current obesity epidemic.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22222895
U2 - 10.1016/j.biocel.2011.12.011
DO - 10.1016/j.biocel.2011.12.011
M3 - Article
SN - 1357-2725
VL - 44
SP - 435
EP - 440
JO - International Journal of Biochemistry & Cell Biology
JF - International Journal of Biochemistry & Cell Biology
IS - 3
ER -
