White adipocytes: More than just fat depots

Sarah L Henry, Jonathan G Bensley, Ryan J Wood-Bradley, Luise A Cullen-McEwen, John F Bertram, James A Armitage

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Abstract

Globally 30 of adults are overweight or obese. The white adipocyte is a major component of adipose tissue, and as the obesity epidemic increases it is critically important to understand the factors determining adipocyte development and function. Adipogenesis has two distinct phases; determination of the adipocyte from a multipotent stem cell, and terminal differentiation of a pre-adipocyte into a mature adipocyte. The environment encountered in early life can alter adipocyte number and size and potentially impact upon adipocyte endocrine function in adulthood. These alterations may contribute to the pathophysiology of chronic diseases and thus targeted therapy of the adipocyte has great potential for treating the current obesity epidemic.
Original languageEnglish
Pages (from-to)435 - 440
Number of pages6
JournalInternational Journal of Biochemistry & Cell Biology
Volume44
Issue number3
DOIs
Publication statusPublished - 2012

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