TY - JOUR
T1 - Where are we in diabetic nephropathy
T2 - MicroRNAs and biomarkers
AU - McClelland, Aaron
AU - Hagiwara, Shinji
AU - Kantharidis, Phillip
PY - 2014/1
Y1 - 2014/1
N2 - PURPOSE OF REVIEW: Several factors are now known to contribute to the development and progression of nephropathy, particularly in diabetes. In recent times, there has been surge of interest in the role of small noncoding RNA, with several reports focusing on the effects of microRNAs on their target genes that are of relevance to nephropathy. This review focuses on recent progress in this field. RECENT FINDINGS: The list of microRNAs that have been identified to play a role in nephropathy continues to grow. Of particular interest is the fact that most microRNAs that are implicated in nephropathy are regulated by the profibrotic factor, transforming growth factor-β. Additionally, some recent studies have used the presence of microRNAs in biofluids as a source of potential biomarkers for many diseases, particularly in diabetic nephropathy. SUMMARY: MicroRNAs hold much promise given their novelty, promiscuity and involvement in many biological and pathological processes. There are promising early signs of their potential as biomarkers as well as therapeutic targets.
AB - PURPOSE OF REVIEW: Several factors are now known to contribute to the development and progression of nephropathy, particularly in diabetes. In recent times, there has been surge of interest in the role of small noncoding RNA, with several reports focusing on the effects of microRNAs on their target genes that are of relevance to nephropathy. This review focuses on recent progress in this field. RECENT FINDINGS: The list of microRNAs that have been identified to play a role in nephropathy continues to grow. Of particular interest is the fact that most microRNAs that are implicated in nephropathy are regulated by the profibrotic factor, transforming growth factor-β. Additionally, some recent studies have used the presence of microRNAs in biofluids as a source of potential biomarkers for many diseases, particularly in diabetic nephropathy. SUMMARY: MicroRNAs hold much promise given their novelty, promiscuity and involvement in many biological and pathological processes. There are promising early signs of their potential as biomarkers as well as therapeutic targets.
KW - biomarkers
KW - fibrosis
KW - microRNA
KW - TGF-β
UR - http://www.scopus.com/inward/record.url?scp=84890547522&partnerID=8YFLogxK
U2 - 10.1097/01.mnh.0000437612.50040.ae
DO - 10.1097/01.mnh.0000437612.50040.ae
M3 - Review Article
C2 - 24247820
AN - SCOPUS:84890547522
SN - 1062-4821
VL - 23
SP - 80
EP - 86
JO - Current Opinion in Nephrology and Hypertension
JF - Current Opinion in Nephrology and Hypertension
IS - 1
ER -