What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

Gustavo Noffs, Thushara Perera, Scott C. Kolbe, Camille J. Shanahan, Frederique M.C. Boonstra, Andrew Evans, Helmut Butzkueven, Anneke van der Walt, Adam P. Vogel

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Importance: Multiple sclerosis produces neurological impairments that are variable in duration, severity and quality. Speech is frequently impaired, resulting in decreased communication skills and quality of life. Advancements in technology now makes it possible to use quantitative acoustic assessment of speech as biomarkers of disease progression. Observations: Four domains of speech have been identified: articulation (slow articulation and imprecise consonants), voice (pitch and loudness instability), respiration (decreased phonatory time and expiratory pressure) and prosody (longer and frequent pauses, deficient loudness control). Studies also explored I) predictive models for diagnosis of MS and of ataxia using speech variables, II) the relationship of dysarthria with cognition and III) very few studies correlated neuroimaging with dysarthria. We could not identify longitudinal studies of speech or dysarthria in Multiple Sclerosis. Conclusion and relevance: Refinement of objective measures of speech has enhanced our understanding of Multiple Sclerosis-related deficits in cross-sectional analysis while both integrative and longitudinal studies are identified as major gaps. This review highlights the potential for using quantitative acoustic assessments as clinical endpoints for diagnosing, monitoring progression and treatment in disease modifying trials.

Original languageEnglish
Pages (from-to)1202-1209
Number of pages8
JournalAutoimmunity Reviews
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 2018
Externally publishedYes

Keywords

  • Acoustics
  • Cognition
  • Deep brain stimulation
  • Dysarthria
  • Dysphonia
  • Multiple sclerosis
  • Quality of life
  • Speech
  • Voice

Cite this

Noffs, G., Perera, T., Kolbe, S. C., Shanahan, C. J., Boonstra, F. M. C., Evans, A., ... Vogel, A. P. (2018). What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis. Autoimmunity Reviews, 17(12), 1202-1209. https://doi.org/10.1016/j.autrev.2018.06.010
Noffs, Gustavo ; Perera, Thushara ; Kolbe, Scott C. ; Shanahan, Camille J. ; Boonstra, Frederique M.C. ; Evans, Andrew ; Butzkueven, Helmut ; van der Walt, Anneke ; Vogel, Adam P. / What speech can tell us : A systematic review of dysarthria characteristics in Multiple Sclerosis. In: Autoimmunity Reviews. 2018 ; Vol. 17, No. 12. pp. 1202-1209.
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What speech can tell us : A systematic review of dysarthria characteristics in Multiple Sclerosis. / Noffs, Gustavo; Perera, Thushara; Kolbe, Scott C.; Shanahan, Camille J.; Boonstra, Frederique M.C.; Evans, Andrew; Butzkueven, Helmut; van der Walt, Anneke; Vogel, Adam P.

In: Autoimmunity Reviews, Vol. 17, No. 12, 12.2018, p. 1202-1209.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Boonstra, Frederique M.C.

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