What is the role of vertebral augmentation for osteoporotic fractures? A review of the recent literature

Stefano Marcia, Mario Muto, Joshua A. Hirsch, Ronil V. Chandra, Nicole Carter, Paola Crivelli, Emanuele Piras, Luca Saba

Research output: Contribution to journalReview ArticleResearchpeer-review

19 Citations (Scopus)


Purpose: Vertebral augmentation procedures such as vertebroplasty and kyphoplasty are utilized in the treatment of vertebral compression fractures (VCFs). However, their capacity for providing analgesia, reducing disability, and improving quality of life in patients with osteoporotic VCFs remains a topic of debate. The objective of this narrative review is to summarize the latest evidence for the safety and efficacy of vertebral augmentation for osteoporotic vertebral compression fractures (VCFs). Methods: A systematic literature search was conducted using the PubMed and Cochrane electronic databases for systematic reviews, review articles, meta-analyses, and randomized clinical trials prior to May 2017. The keywords were “vertebroplasty,” “kyphoplasty,” and “vertebral augmentation.” Results: Thirty-three papers (7 systematic reviews, 6 cohort studies, 15 randomized clinical trials, and 5 international guidelines) were included in this narrative review. Conclusion: Vertebral augmentation is a safe procedure, with low rates of serious complications and no increase in subsequent post-treatment fracture risk.

Original languageEnglish
Pages (from-to)777-783
Number of pages7
Issue number8
Publication statusPublished - 1 Aug 2018


  • Kyphoplasty
  • Osteoporosis
  • Vertebral augmentation
  • Vertebral fracture
  • Vertebroplasty

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