What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?

Jean-Pierre Pelletier, Cyrus Cooper, Charles Peterfy, Jean Reginster, Maria Louisa Brandi, Olivier Bruyere, Roland Chapurlat, Flavia Maria Cicuttini, Philip Conaghan, Michael Doherty, Harry K Genant, Giampaolo Giacovelli, Marc C Hochberg, David Hunter, John A Kanis, Margreet G Kloppenburg, Jean Laredo, Timothy McAlindon, Michael C Nevitt, Jean-Pierre RaynauldRene Rizzoli, Christoph Zilkens, Frank W Roemer, Johanne Martel-Pelletier, Ali Guermazi

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Abstract

Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited. An alternative is virtual knee replacement on the basis of symptoms and structural damage. MRI may prove to be a good alternative to radiography in definitions of knee replacement. One of the MRI parameters that predicts knee replacement is medial compartment cartilage volume/thickness, which correlates with radiographic joint space width, is sensitive to change, and predicts outcomes in a continuous manner. Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement
Original languageEnglish
Pages (from-to)1594 - 1604
Number of pages11
JournalAnnals of the Rheumatic Diseases
Volume72
Issue number10
DOIs
Publication statusPublished - 2013

Cite this

Pelletier, J-P., Cooper, C., Peterfy, C., Reginster, J., Brandi, M. L., Bruyere, O., Chapurlat, R., Cicuttini, F. M., Conaghan, P., Doherty, M., Genant, H. K., Giacovelli, G., Hochberg, M. C., Hunter, D., Kanis, J. A., Kloppenburg, M. G., Laredo, J., McAlindon, T., Nevitt, M. C., ... Guermazi, A. (2013). What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis? Annals of the Rheumatic Diseases, 72(10), 1594 - 1604. https://doi.org/10.1136/annrheumdis-2013-203631