What can we do if clozapine fails? Pharmacologic choices and differential outcomes

David Jonathan Castle, Nicholas Keks

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)


What to do when clozapine therapy (or other medications) does not work … or, more often, doesn’t work well enough? This is a real clinical conundrum. Moreover, clinicians struggle daily with the dilemma of distilling information on appropriate augmentation strategies from studies of groups of patients and thereupon extrapolating that information to the individual patient in their practice. This is a complicated equation at the time when the clinician and/or the patient conclude that clozapine therapy has reached its plateau and other options are called for. This chapter will detail the range of options as well as some considerations for selecting one choice over another for given patient scenarios.

Original languageEnglish
Title of host publicationTreatment-Refractory Schizophrenia: A Clinical Conundrum
EditorsPeter F. Buckley, Fiona Gaughran
Place of PublicationBerlin Germany
Number of pages14
ISBN (Electronic)9783642452574
ISBN (Print)9783642452567
Publication statusPublished - 1 Jan 2014

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