Wet spheronization by rotary processing - a multistage single-pot process for producing spheroids

L. Gu, C. V. Liew, P. W.S. Heng

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)


Spheronization is an agglomerative size enlargement process for producing spherical agglomerates that have many technological and therapeutical advantages. Rotary processing is an efficient multistage, single-pot spheroid production method. The rotary processor can be used for spheroid production, drying as well as coating. In the course of spheroid production, centrifugal, fluidizing, and gravitational forces act upon the product from different directions and collectively contribute to the spheroid formation process during rotary processing. The outcome of the process depends on the complex interactions between the equipment, formulation, and process variables.

Original languageEnglish
Pages (from-to)111-123
Number of pages13
JournalDrug Development and Industrial Pharmacy
Issue number2
Publication statusPublished - 2004
Externally publishedYes


  • Rotary processing
  • Spheroids
  • Wet spheronization

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