Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

Lisa J. Moran; Manny Noakes; Gary A. Wittert; Peter M Clifton; Robert J Norman

doi:10.1016/j.rbmo.2012.07.013

Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

Lisa J. Moran, Manny Noakes, Gary A. Wittert, Peter M Clifton, Robert J Norman

Monash Centre for Health Research and Implementation

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.

Original language	English
Pages (from-to)	500-503
Number of pages	4
Journal	Reproductive BioMedicine Online
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.rbmo.2012.07.013
Publication status	Published - Nov 2012

Keywords

cardiovascular disease
inflammation
polycystic ovary syndrome
weight loss

Access to Document

10.1016/j.rbmo.2012.07.013

Link to publication in Scopus

Cite this

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title = "Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome",

abstract = "Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss.",

keywords = "cardiovascular disease, inflammation, polycystic ovary syndrome, weight loss",

author = "Moran, {Lisa J.} and Manny Noakes and Wittert, {Gary A.} and Clifton, {Peter M} and Norman, {Robert J}",

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AU - Norman, Robert J

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