Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components

GJ Ooi, L Doyle, T Tie, JM Wentworth, C Laurie, A Earnest, MA Cowley, K Sikaris, CW le Roux, PR Burton, Paul O'Brien, WA Brown

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Background:Substantial weight loss in the setting of obesity has considerable metabolic benefits. Yet some studies have shown improvements in obesity-related metabolic comorbidities with more modest weight loss. By closely monitoring patients undergoing bariatric surgery, we aimed to determine the effects of weight loss on the metabolic syndrome and its components and determine the weight loss required for their resolution.Methods:We performed a prospective observational study of obese participants with metabolic syndrome (Adult Treatment Panel III criteria) who underwent laparoscopic adjustable gastric banding. Participants were assessed for all criteria of the metabolic syndrome monthly for the first 9 months, then 3-monthly until 24 months.Results:There were 89 participants with adequate longitudinal data. Baseline body mass index was 42.4±6.2 kg m-2 with an average age was 48.2±10.7 years. There were 56 (63%) women. Resolution of the metabolic syndrome occurred in 60 of the 89 participants (67%) at 12 months and 60 of the 75 participants (80%) at 24 months. The mean weight loss when metabolic syndrome resolved was 10.9±7.7% total body weight loss (TBWL). The median weight loss at which prevalence of disease halved was 7.0% TBWL (17.5% excess weight loss (EWL)) for hypertriglyceridaemia; 11% TBWL (26.1–28% EWL) for high-density lipoprotein cholesterol and hyperglycaemia; 20% TBWL (59.5% EWL) for hypertension and 29% TBWL (73.3% EWL) for waist circumference. The odds ratio for resolution of the metabolic syndrome with 10–12.5% TBWL was 2.09 (P=0.025), with increasing probability of resolution with more substantial weight loss.Conclusions:In obese participants with metabolic syndrome, a weight loss target of 10–12.5% TBWL (25–30% EWL) is a reasonable initial goal associated with significant odds of having metabolic benefits. If minimal improvements are seen with this initial target, additional weight loss substantially increases the probability of resolution.

Original languageEnglish
Pages (from-to)902-908
Number of pages7
JournalInternational Journal of Obesity
Volume41
DOIs
Publication statusPublished - 21 Mar 2017

Cite this

@article{8ddcd288498f440889043defd81596f5,
title = "Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components",
abstract = "Background:Substantial weight loss in the setting of obesity has considerable metabolic benefits. Yet some studies have shown improvements in obesity-related metabolic comorbidities with more modest weight loss. By closely monitoring patients undergoing bariatric surgery, we aimed to determine the effects of weight loss on the metabolic syndrome and its components and determine the weight loss required for their resolution.Methods:We performed a prospective observational study of obese participants with metabolic syndrome (Adult Treatment Panel III criteria) who underwent laparoscopic adjustable gastric banding. Participants were assessed for all criteria of the metabolic syndrome monthly for the first 9 months, then 3-monthly until 24 months.Results:There were 89 participants with adequate longitudinal data. Baseline body mass index was 42.4±6.2 kg m-2 with an average age was 48.2±10.7 years. There were 56 (63{\%}) women. Resolution of the metabolic syndrome occurred in 60 of the 89 participants (67{\%}) at 12 months and 60 of the 75 participants (80{\%}) at 24 months. The mean weight loss when metabolic syndrome resolved was 10.9±7.7{\%} total body weight loss (TBWL). The median weight loss at which prevalence of disease halved was 7.0{\%} TBWL (17.5{\%} excess weight loss (EWL)) for hypertriglyceridaemia; 11{\%} TBWL (26.1–28{\%} EWL) for high-density lipoprotein cholesterol and hyperglycaemia; 20{\%} TBWL (59.5{\%} EWL) for hypertension and 29{\%} TBWL (73.3{\%} EWL) for waist circumference. The odds ratio for resolution of the metabolic syndrome with 10–12.5{\%} TBWL was 2.09 (P=0.025), with increasing probability of resolution with more substantial weight loss.Conclusions:In obese participants with metabolic syndrome, a weight loss target of 10–12.5{\%} TBWL (25–30{\%} EWL) is a reasonable initial goal associated with significant odds of having metabolic benefits. If minimal improvements are seen with this initial target, additional weight loss substantially increases the probability of resolution.",
author = "GJ Ooi and L Doyle and T Tie and JM Wentworth and C Laurie and A Earnest and MA Cowley and K Sikaris and {le Roux}, CW and PR Burton and Paul O'Brien and WA Brown",
year = "2017",
month = "3",
day = "21",
doi = "10.1038/ijo.2017.59",
language = "English",
volume = "41",
pages = "902--908",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",

}

Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components. / Ooi, GJ; Doyle, L; Tie, T; Wentworth, JM; Laurie, C; Earnest, A; Cowley, MA; Sikaris, K; le Roux, CW; Burton, PR; O'Brien, Paul; Brown, WA.

In: International Journal of Obesity, Vol. 41, 21.03.2017, p. 902-908.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components

AU - Ooi, GJ

AU - Doyle, L

AU - Tie, T

AU - Wentworth, JM

AU - Laurie, C

AU - Earnest, A

AU - Cowley, MA

AU - Sikaris, K

AU - le Roux, CW

AU - Burton, PR

AU - O'Brien, Paul

AU - Brown, WA

PY - 2017/3/21

Y1 - 2017/3/21

N2 - Background:Substantial weight loss in the setting of obesity has considerable metabolic benefits. Yet some studies have shown improvements in obesity-related metabolic comorbidities with more modest weight loss. By closely monitoring patients undergoing bariatric surgery, we aimed to determine the effects of weight loss on the metabolic syndrome and its components and determine the weight loss required for their resolution.Methods:We performed a prospective observational study of obese participants with metabolic syndrome (Adult Treatment Panel III criteria) who underwent laparoscopic adjustable gastric banding. Participants were assessed for all criteria of the metabolic syndrome monthly for the first 9 months, then 3-monthly until 24 months.Results:There were 89 participants with adequate longitudinal data. Baseline body mass index was 42.4±6.2 kg m-2 with an average age was 48.2±10.7 years. There were 56 (63%) women. Resolution of the metabolic syndrome occurred in 60 of the 89 participants (67%) at 12 months and 60 of the 75 participants (80%) at 24 months. The mean weight loss when metabolic syndrome resolved was 10.9±7.7% total body weight loss (TBWL). The median weight loss at which prevalence of disease halved was 7.0% TBWL (17.5% excess weight loss (EWL)) for hypertriglyceridaemia; 11% TBWL (26.1–28% EWL) for high-density lipoprotein cholesterol and hyperglycaemia; 20% TBWL (59.5% EWL) for hypertension and 29% TBWL (73.3% EWL) for waist circumference. The odds ratio for resolution of the metabolic syndrome with 10–12.5% TBWL was 2.09 (P=0.025), with increasing probability of resolution with more substantial weight loss.Conclusions:In obese participants with metabolic syndrome, a weight loss target of 10–12.5% TBWL (25–30% EWL) is a reasonable initial goal associated with significant odds of having metabolic benefits. If minimal improvements are seen with this initial target, additional weight loss substantially increases the probability of resolution.

AB - Background:Substantial weight loss in the setting of obesity has considerable metabolic benefits. Yet some studies have shown improvements in obesity-related metabolic comorbidities with more modest weight loss. By closely monitoring patients undergoing bariatric surgery, we aimed to determine the effects of weight loss on the metabolic syndrome and its components and determine the weight loss required for their resolution.Methods:We performed a prospective observational study of obese participants with metabolic syndrome (Adult Treatment Panel III criteria) who underwent laparoscopic adjustable gastric banding. Participants were assessed for all criteria of the metabolic syndrome monthly for the first 9 months, then 3-monthly until 24 months.Results:There were 89 participants with adequate longitudinal data. Baseline body mass index was 42.4±6.2 kg m-2 with an average age was 48.2±10.7 years. There were 56 (63%) women. Resolution of the metabolic syndrome occurred in 60 of the 89 participants (67%) at 12 months and 60 of the 75 participants (80%) at 24 months. The mean weight loss when metabolic syndrome resolved was 10.9±7.7% total body weight loss (TBWL). The median weight loss at which prevalence of disease halved was 7.0% TBWL (17.5% excess weight loss (EWL)) for hypertriglyceridaemia; 11% TBWL (26.1–28% EWL) for high-density lipoprotein cholesterol and hyperglycaemia; 20% TBWL (59.5% EWL) for hypertension and 29% TBWL (73.3% EWL) for waist circumference. The odds ratio for resolution of the metabolic syndrome with 10–12.5% TBWL was 2.09 (P=0.025), with increasing probability of resolution with more substantial weight loss.Conclusions:In obese participants with metabolic syndrome, a weight loss target of 10–12.5% TBWL (25–30% EWL) is a reasonable initial goal associated with significant odds of having metabolic benefits. If minimal improvements are seen with this initial target, additional weight loss substantially increases the probability of resolution.

UR - http://www.scopus.com/inward/record.url?scp=85015623629&partnerID=8YFLogxK

U2 - 10.1038/ijo.2017.59

DO - 10.1038/ijo.2017.59

M3 - Article

VL - 41

SP - 902

EP - 908

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -