Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators

Margarita Garcia; Matthew P. Beecham; Kristian Kempe; David M. Haddleton; Afzal Khan; Andrew Marsh

doi:10.1016/j.eurpolymj.2015.03.014

Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators

Margarita Garcia, Matthew P. Beecham, Kristian Kempe, David M. Haddleton, Afzal Khan, Andrew Marsh

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

Abstract The monomers methacryloyl uridine and methacryloyl adenosine have been polymerised under copper-mediated living radical conditions using poly(ethylene glycol) (PEG) macroinitiators to give triblock and pentablock copolymers of reasonable dispersity. The triblocks were used as initiators for the successful synthesis of pentablock copolymers. The secondary structures of the triblock and pentablock copolymers have been investigated using circular dichroism (CD) spectroscopy. The adenosine copolymers are found to exhibit more ordered secondary structures in water in comparison to the uridine derived polymers. New supramolecular structure is observed by CD upon mixing adenosine and uridine triblock copolymers in water. The polymers obtained are of interest as potential drug delivery agents through interaction with small molecules and oligonucelotides.

Original language	English
Pages (from-to)	444-451
Number of pages	8
Journal	European Polymer Journal
Volume	66
DOIs	https://doi.org/10.1016/j.eurpolymj.2015.03.014
Publication status	Published - 2015
Externally published	Yes

Keywords

Circular dichroism
Copper-mediated polymerization
Nucleobase
Nucleoside
Secondary structure
Supramolecular

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title = "Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators",

abstract = "Abstract The monomers methacryloyl uridine and methacryloyl adenosine have been polymerised under copper-mediated living radical conditions using poly(ethylene glycol) (PEG) macroinitiators to give triblock and pentablock copolymers of reasonable dispersity. The triblocks were used as initiators for the successful synthesis of pentablock copolymers. The secondary structures of the triblock and pentablock copolymers have been investigated using circular dichroism (CD) spectroscopy. The adenosine copolymers are found to exhibit more ordered secondary structures in water in comparison to the uridine derived polymers. New supramolecular structure is observed by CD upon mixing adenosine and uridine triblock copolymers in water. The polymers obtained are of interest as potential drug delivery agents through interaction with small molecules and oligonucelotides.",

keywords = "Circular dichroism, Copper-mediated polymerization, Nucleobase, Nucleoside, Secondary structure, Supramolecular",

author = "Margarita Garcia and Beecham, {Matthew P.} and Kristian Kempe and Haddleton, {David M.} and Afzal Khan and Andrew Marsh",

year = "2015",

doi = "10.1016/j.eurpolymj.2015.03.014",

language = "English",

volume = "66",

pages = "444--451",

journal = "European Polymer Journal",

issn = "0014-3057",

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TY - JOUR

T1 - Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators

AU - Garcia, Margarita

AU - Beecham, Matthew P.

AU - Kempe, Kristian

AU - Haddleton, David M.

AU - Khan, Afzal

AU - Marsh, Andrew

PY - 2015

Y1 - 2015

N2 - Abstract The monomers methacryloyl uridine and methacryloyl adenosine have been polymerised under copper-mediated living radical conditions using poly(ethylene glycol) (PEG) macroinitiators to give triblock and pentablock copolymers of reasonable dispersity. The triblocks were used as initiators for the successful synthesis of pentablock copolymers. The secondary structures of the triblock and pentablock copolymers have been investigated using circular dichroism (CD) spectroscopy. The adenosine copolymers are found to exhibit more ordered secondary structures in water in comparison to the uridine derived polymers. New supramolecular structure is observed by CD upon mixing adenosine and uridine triblock copolymers in water. The polymers obtained are of interest as potential drug delivery agents through interaction with small molecules and oligonucelotides.

AB - Abstract The monomers methacryloyl uridine and methacryloyl adenosine have been polymerised under copper-mediated living radical conditions using poly(ethylene glycol) (PEG) macroinitiators to give triblock and pentablock copolymers of reasonable dispersity. The triblocks were used as initiators for the successful synthesis of pentablock copolymers. The secondary structures of the triblock and pentablock copolymers have been investigated using circular dichroism (CD) spectroscopy. The adenosine copolymers are found to exhibit more ordered secondary structures in water in comparison to the uridine derived polymers. New supramolecular structure is observed by CD upon mixing adenosine and uridine triblock copolymers in water. The polymers obtained are of interest as potential drug delivery agents through interaction with small molecules and oligonucelotides.

KW - Circular dichroism

KW - Copper-mediated polymerization

KW - Nucleobase

KW - Nucleoside

KW - Secondary structure

KW - Supramolecular

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U2 - 10.1016/j.eurpolymj.2015.03.014

DO - 10.1016/j.eurpolymj.2015.03.014

M3 - Article

AN - SCOPUS:84925590053

VL - 66

SP - 444

EP - 451

JO - European Polymer Journal

JF - European Polymer Journal

SN - 0014-3057

ER -

Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators

Abstract

Keywords

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