Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators

Margarita Garcia, Matthew P. Beecham, Kristian Kempe, David M. Haddleton, Afzal Khan, Andrew Marsh

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Abstract The monomers methacryloyl uridine and methacryloyl adenosine have been polymerised under copper-mediated living radical conditions using poly(ethylene glycol) (PEG) macroinitiators to give triblock and pentablock copolymers of reasonable dispersity. The triblocks were used as initiators for the successful synthesis of pentablock copolymers. The secondary structures of the triblock and pentablock copolymers have been investigated using circular dichroism (CD) spectroscopy. The adenosine copolymers are found to exhibit more ordered secondary structures in water in comparison to the uridine derived polymers. New supramolecular structure is observed by CD upon mixing adenosine and uridine triblock copolymers in water. The polymers obtained are of interest as potential drug delivery agents through interaction with small molecules and oligonucelotides.

Original languageEnglish
Pages (from-to)444-451
Number of pages8
JournalEuropean Polymer Journal
Volume66
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Circular dichroism
  • Copper-mediated polymerization
  • Nucleobase
  • Nucleoside
  • Secondary structure
  • Supramolecular

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