Organs such as the heart and kidney would survive cryopreservation at liquid nitrogen temperatures if the mechanical damage caused by the freezing of ice during cooling could be avoided. The approach is to introduce a sufficiently high concentration of solutes into the cells which make up the organ that both the intracellular and extracellular solutions would become glass forming during cooling, thus bypassing the crystallization process. It is thus of importance to this effort to have a range of water-soluble polymers available of varying structure, and in this article we report the preparation of a novel siloxane polymer which has been rendered water soluble by the attachment of poly(ethylene glycol) side groups. An interesting feature of water-soluble polymers with this type of structure is that the long side groups could effect a decrease in the size of the ice crystals with the addition of only small amounts of polymer and possibly reduce tissue damage.
|Number of pages||3|
|Journal||Journal of Polymer Science. Polymer Letters Edition|
|Publication status||Published - 1 Jan 1985|