Water-soluble and pH-responsive polymeric nanotubes from cyclic peptide templates

Robert Chapman, Gregory G. Warr, Sebastien Perrier, Katrina A. Jolliffe

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

Water-soluble organic nanotubes were prepared by convergently conjugating polymers of hydroxyethyl acrylate (HEA) and acrylic acid (AA) to self-assembling cyclic octapeptides of alternating d and l chirality. The structure of the self-assembled tubes was characterised in a number of polar solvents, and notably water, by using light scattering, TEM and small angle neutron scattering (SANS) techniques. In addition, the self-assembly into tubes could be controlled by exploiting the pH responsiveness of acrylic acid polymers. 

Original languageEnglish
Pages (from-to)1955-1961
Number of pages7
JournalChemistry - A European Journal
Volume19
Issue number6
DOIs
Publication statusPublished - 4 Feb 2013
Externally publishedYes

Keywords

  • nanotubes
  • peptides
  • polymers
  • self-assembly

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