VSV G protein induces murine cytolytic T lymphocytes

Carol S. Reiss, Steve S.L. Chen, Alice S. Huang, Richard Doherty

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Abstract

Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalMicrobial Pathogenesis
Volume1
Issue number3
DOIs
Publication statusPublished - Jun 1986
Externally publishedYes

Keywords

  • cytolytic T lymphocytes
  • immunity
  • neutralizing antibody
  • VSV G protein

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