VSV G protein induces murine cytolytic T lymphocytes

Carol S. Reiss; Steve S.L. Chen; Alice S. Huang; Richard Doherty

doi:10.1016/0882-4010(86)90050-1

VSV G protein induces murine cytolytic T lymphocytes

Carol S. Reiss, Steve S.L. Chen, Alice S. Huang, Richard Doherty

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.

Original language	English
Pages (from-to)	261-267
Number of pages	7
Journal	Microbial Pathogenesis
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0882-4010(86)90050-1
Publication status	Published - Jun 1986
Externally published	Yes

Keywords

cytolytic T lymphocytes
immunity
neutralizing antibody
VSV G protein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0882-4010(86)90050-1

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title = "VSV G protein induces murine cytolytic T lymphocytes",

abstract = "Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.",

keywords = "cytolytic T lymphocytes, immunity, neutralizing antibody, VSV G protein",

author = "Reiss, {Carol S.} and Chen, {Steve S.L.} and Huang, {Alice S.} and Richard Doherty",

note = "Funding Information: The authors would like to thank MS Trudy Lanman for technical support and MS lreta Ashby for assistance in manuscript preparation. C.S.R. was supported by an American Cancer Society Junior Faculty Research Award (JFRA 107) and a grant from the National Institutes of Health (Al 18083). RD. was a Harkness Fellow of the Commonwealth Fund, NY. A.S.H. and S.S.L.C. are supported by a NIH research grant (Al 20896).",

year = "1986",

month = jun,

doi = "10.1016/0882-4010(86)90050-1",

language = "English",

volume = "1",

pages = "261--267",

journal = "Microbial Pathogenesis",

issn = "0882-4010",

publisher = "Academic Press",

number = "3",

}

TY - JOUR

T1 - VSV G protein induces murine cytolytic T lymphocytes

AU - Reiss, Carol S.

AU - Chen, Steve S.L.

AU - Huang, Alice S.

AU - Doherty, Richard

N1 - Funding Information: The authors would like to thank MS Trudy Lanman for technical support and MS lreta Ashby for assistance in manuscript preparation. C.S.R. was supported by an American Cancer Society Junior Faculty Research Award (JFRA 107) and a grant from the National Institutes of Health (Al 18083). RD. was a Harkness Fellow of the Commonwealth Fund, NY. A.S.H. and S.S.L.C. are supported by a NIH research grant (Al 20896).

PY - 1986/6

Y1 - 1986/6

N2 - Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.

AB - Mice immunized with vesicular stomatitis virus (VSV), with its glycoprotein (G) in lipid vesicles or with a truncated, soluble form of G called Gs, developed an expanded population of virus specific cytolytic T lymphocyte (CTL) precursors and also led to the production of neutralizing serum antibody. The CTL precursors could be restimulated in vitro with either the virus or its glycoprotein components. Thus the glycoprotein of VSV, either associated with lipids or in soluble form, induced both cellular and humoral immune responses that might be sufficient to result in protective immunity.

KW - cytolytic T lymphocytes

KW - immunity

KW - neutralizing antibody

KW - VSV G protein

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U2 - 10.1016/0882-4010(86)90050-1

DO - 10.1016/0882-4010(86)90050-1

M3 - Article

C2 - 2854599

AN - SCOPUS:0022484073

SN - 0882-4010

VL - 1

SP - 261

EP - 267

JO - Microbial Pathogenesis

JF - Microbial Pathogenesis

IS - 3

ER -

VSV G protein induces murine cytolytic T lymphocytes

Abstract

Keywords

UN SDGs

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