Voxelwise regularisation of high angular resolution diffusion imaging data

Leigh A Johnston, Scott Kolbe, Iven M Y Mareels, Gary Egan

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

The problem of noise suppression in high angular resolution diffusion MRI data is approached through direct regularisation of the apparent diffusion coefficient profiles. The proposed algorithm is derived in a Bayesian framework in the style of the traditional techniques for image restoration using Markov random field models. In a novel departure from the classical approach, a Markov random field model is applied within each voxel across gradient directions, thus smoothing the image data without inducing additional spatial dependencies that would render region-of-interest statistical testing of diffusion characteristics invalid. The anisotropic smoothing algorithm exploits the heterogeneous distribution of gradient directions and their antipodal pairs on the sphere and, in application to both simulated and experimental high angular resolution imaging datasets, is demonstrated to be superior to the isotropic Markov random field variant and the maximum likelihood estimator.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
EditorsK Chon, A Lain, P Bonato, P Vicini, M Khoo, R Buetra, B Layton, J Patton, D Panescu, N Lovell, J Monzon
Place of PublicationUSA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages90-93
Number of pages4
Volume30
ISBN (Print)9781424418152
DOIs
Publication statusPublished - 1 Dec 2008
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2008 - Vancouver Convention and Exhibition Centre, Vancouver, Canada
Duration: 20 Aug 200825 Aug 2008
Conference number: 30th
https://ieeexplore.ieee.org/xpl/conhome/4636107/proceeding (Proceedings)

Publication series

NameProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2008
Abbreviated titleEMBS 2008
CountryCanada
CityVancouver
Period20/08/0825/08/08
Internet address

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