Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder

Emre Bora, Alexander Fornito, Murat Yucel, Christos Pantelis

Research output: Contribution to journalArticleResearchpeer-review

282 Citations (Scopus)


We conducted a meta-analysis of gray matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studies to help clarify the structural abnormalities underpinning this condition. Methods: A systematic review was conducted for voxel-based morphometry studies of patients with BD. Meta-analyses of gray matter differences between BD and control subjects were undertaken using signed differential mapping, a novel method that, in contrast to previously used techniques, allows inclusion of negative findings and ensures that single studies do not exert undue influence on the results. Meta-regression and subgroup analyses were used to examine the effect of moderator variables on gray matter abnormalities.
Original languageEnglish
Pages (from-to)1097 - 1105
Number of pages9
JournalBiological Psychiatry
Issue number11
Publication statusPublished - 2010
Externally publishedYes

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