TY - JOUR
T1 - Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder
AU - Bora, Emre
AU - Fornito, Alexander
AU - Yucel, Murat
AU - Pantelis, Christos
PY - 2010
Y1 - 2010
N2 - We conducted a meta-analysis of gray matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studies to help clarify the structural abnormalities underpinning this condition. Methods: A systematic review was conducted for voxel-based morphometry studies of patients with BD. Meta-analyses of gray matter differences between BD and control subjects were undertaken using signed differential mapping, a novel method that, in contrast to previously used techniques, allows inclusion of negative findings and ensures that single studies do not exert undue influence on the results. Meta-regression and subgroup analyses were used to examine the effect of moderator variables on gray matter abnormalities.
AB - We conducted a meta-analysis of gray matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studies to help clarify the structural abnormalities underpinning this condition. Methods: A systematic review was conducted for voxel-based morphometry studies of patients with BD. Meta-analyses of gray matter differences between BD and control subjects were undertaken using signed differential mapping, a novel method that, in contrast to previously used techniques, allows inclusion of negative findings and ensures that single studies do not exert undue influence on the results. Meta-regression and subgroup analyses were used to examine the effect of moderator variables on gray matter abnormalities.
UR - http://ac.els-cdn.com/S0006322310000624/1-s2.0-S0006322310000624-main.pdf?_tid=323c6884-2978-11e3-bf0f-00000aab0f26&acdnat=1380508376_3b8c930b67c96bee
U2 - 10.1016/j.biopsych.2010.01.020
DO - 10.1016/j.biopsych.2010.01.020
M3 - Article
VL - 67
SP - 1097
EP - 1105
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 11
ER -