Volumetric differences in the anterior cingulate cortex prospectively predict alcohol-related problems in adolescence

Individual differences in brain structure and function are suggested to exist prior to the onset of alcohol abuse. Cross-sectional studies have demonstrated abnormalities in brain regions underlying affective processes that may form a pathway to the emergence of later alcohol abuse and dependence in vulnerable individuals. However, no prospective studies have examined whether these abnormalities predict later problems with alcohol. Objective: This study aims to examine whether individual differences in affect and brain volume prospectively predict alcohol-related problems in adolescence.