Voltammetric determination of salicylic acid in pharmaceuticals formulations of acetylsalicylic acid

Angel Alberto Jesus Torriero, Juan M Luco, Leonides Sereno, Julio Raba

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82 Citations (Scopus)

Abstract

The electrochem. oxidn. of salicylic acid (SA) was studied on a glassy C electrode using cyclic voltammetry and differential pulse voltammetric (DPV) method. SA gives a single irreversible oxidn. wave over the wide pH range studied. The irreversibility of the electrode process was verified by different criteria. The mechanism of oxidn. is discussed. Using differential pulse voltammetry, SA yielded a well-defined voltammetric response in Britton-Robinson buffer soln., pH 2.37 at 1.088 V (vs. Ag/AgCl). The method was linear over the SA concn. range: 1-60 micro g ml-1. The method was successfully applied for the anal. of SA as a hydrolysis product, in solid pharmaceutical formulations contg. acetylsalicylic acid (ASA). [on SciFinder (R)]
Original languageEnglish
Pages (from-to)247 - 254
Number of pages8
JournalTalanta
Volume62
Issue number2
Publication statusPublished - 2004
Externally publishedYes

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