The origin of the current practice of administering Vitex agnus-castus in menopause-related complaints is uncertain, but appears to be relatively recent. Here we review the evidence for this application of Vitex based on evidence from pharmacological studies and clinical research.
Van Die, D. M., Burger, H. G., Teede, H. J., & Bone, K. M. (2009). Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints. Journal of Alternative and Complementary Medicine, 15(8), 853 - 862. https://doi.org/10.1089/acm.2008.0447