Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection

Matthew Kitson, Gregory J Dore, Jacob George, Geoffrey McCaughan, Darrell Crawford, William Sievert, Martin D Weltman, Wendy Cheng, Stuart Keith Roberts

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Abstract

BACKGROUND AIMS: The relationship between vitamin D status and response to antiviral therapy and liver histology in hepatitis C virus genotype 1 (HCV-1) infection remains unclear, with studies to date yielding inconsistent results and failing to use reference assay methodology. We therefore analyzed pre-treatment 25-hydroxyvitamin D [25(OH)D] level, using reference liquid chromatography-tandem mass spectrometry methodology, in a cohort of treatment-naive patients with HCV-1 to evaluate the association between vitamin D status, virologic response, and liver histology. METHODS: 274 patients, with pre-treatment liver biopsy and up to 48 weeks of pegylated interferon alfa-2a plus ribavirin therapy, were tested for serum 25(OH)D level. Predictors of sustained virologic response (SVR), and variables associated with fibrosis stage, activity grade and 25(OH)D status were identified using multivariate analysis. RESULTS: Mean 25(OH)D level was 79.6 nmol/L, with a prevalence of 25(OH)D
Original languageEnglish
Pages (from-to)467 - 472
Number of pages6
JournalJournal of Hepatology
Volume58
Issue number3
DOIs
Publication statusPublished - 2013

Cite this

Kitson, Matthew ; Dore, Gregory J ; George, Jacob ; McCaughan, Geoffrey ; Crawford, Darrell ; Sievert, William ; Weltman, Martin D ; Cheng, Wendy ; Roberts, Stuart Keith. / Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection. In: Journal of Hepatology. 2013 ; Vol. 58, No. 3. pp. 467 - 472.
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abstract = "BACKGROUND AIMS: The relationship between vitamin D status and response to antiviral therapy and liver histology in hepatitis C virus genotype 1 (HCV-1) infection remains unclear, with studies to date yielding inconsistent results and failing to use reference assay methodology. We therefore analyzed pre-treatment 25-hydroxyvitamin D [25(OH)D] level, using reference liquid chromatography-tandem mass spectrometry methodology, in a cohort of treatment-naive patients with HCV-1 to evaluate the association between vitamin D status, virologic response, and liver histology. METHODS: 274 patients, with pre-treatment liver biopsy and up to 48 weeks of pegylated interferon alfa-2a plus ribavirin therapy, were tested for serum 25(OH)D level. Predictors of sustained virologic response (SVR), and variables associated with fibrosis stage, activity grade and 25(OH)D status were identified using multivariate analysis. RESULTS: Mean 25(OH)D level was 79.6 nmol/L, with a prevalence of 25(OH)D",
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Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection. / Kitson, Matthew; Dore, Gregory J; George, Jacob; McCaughan, Geoffrey; Crawford, Darrell; Sievert, William; Weltman, Martin D; Cheng, Wendy; Roberts, Stuart Keith.

In: Journal of Hepatology, Vol. 58, No. 3, 2013, p. 467 - 472.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection

AU - Kitson, Matthew

AU - Dore, Gregory J

AU - George, Jacob

AU - McCaughan, Geoffrey

AU - Crawford, Darrell

AU - Sievert, William

AU - Weltman, Martin D

AU - Cheng, Wendy

AU - Roberts, Stuart Keith

PY - 2013

Y1 - 2013

N2 - BACKGROUND AIMS: The relationship between vitamin D status and response to antiviral therapy and liver histology in hepatitis C virus genotype 1 (HCV-1) infection remains unclear, with studies to date yielding inconsistent results and failing to use reference assay methodology. We therefore analyzed pre-treatment 25-hydroxyvitamin D [25(OH)D] level, using reference liquid chromatography-tandem mass spectrometry methodology, in a cohort of treatment-naive patients with HCV-1 to evaluate the association between vitamin D status, virologic response, and liver histology. METHODS: 274 patients, with pre-treatment liver biopsy and up to 48 weeks of pegylated interferon alfa-2a plus ribavirin therapy, were tested for serum 25(OH)D level. Predictors of sustained virologic response (SVR), and variables associated with fibrosis stage, activity grade and 25(OH)D status were identified using multivariate analysis. RESULTS: Mean 25(OH)D level was 79.6 nmol/L, with a prevalence of 25(OH)D

AB - BACKGROUND AIMS: The relationship between vitamin D status and response to antiviral therapy and liver histology in hepatitis C virus genotype 1 (HCV-1) infection remains unclear, with studies to date yielding inconsistent results and failing to use reference assay methodology. We therefore analyzed pre-treatment 25-hydroxyvitamin D [25(OH)D] level, using reference liquid chromatography-tandem mass spectrometry methodology, in a cohort of treatment-naive patients with HCV-1 to evaluate the association between vitamin D status, virologic response, and liver histology. METHODS: 274 patients, with pre-treatment liver biopsy and up to 48 weeks of pegylated interferon alfa-2a plus ribavirin therapy, were tested for serum 25(OH)D level. Predictors of sustained virologic response (SVR), and variables associated with fibrosis stage, activity grade and 25(OH)D status were identified using multivariate analysis. RESULTS: Mean 25(OH)D level was 79.6 nmol/L, with a prevalence of 25(OH)D

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