Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats

Marianne Tare, Sarah Emmett, Harold Coleman, Con Skordilis, Darryl Eyles, Ruth Morley, Helena Parkington

Research output: Contribution to journalArticleResearchpeer-review

128 Citations (Scopus)

Abstract

Increasing evidence links vitamin D deficiency and cardiovascular dysfunction in human adults. There is a worldwide increase in the prevalence of Vitamin D deficiency in women of reproductive age, particularly dark-skinned and/or veiled women and their infants. We used a rat model to determine the functional impact of vitamin D deficiency during intra uterine and early life on resistance artery reactivity and blood pressure in the offspring as young adults. Rat dams were maintained on vitamin D deficient or replete chow before and during pregnancy and lactation. The offspring were maintained on the same chow until studied at 7-8 weeks of age. Conscious blood pressure was measured. Endothelial and smooth muscle function were tested in mesenteric arteries on a pressure myograph. Vitamin D deficient male and female offspring had a ten-fold lower serum 25-hydroxyvitamin D (p
Original languageEnglish
Pages (from-to)4777 - 4786
Number of pages10
JournalThe Journal of Physiology
Volume589
Issue number19
DOIs
Publication statusPublished - 2011

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