Vitamin D in autoimmunity: Molecular mechanisms and therapeutic potential

Wendy Dankers, Edgar M. Colin, Jan Piet van Hamburg, Erik Lubberts

Research output: Contribution to journalReview ArticleResearchpeer-review

131 Citations (Scopus)

Abstract

Over the last three decades, it has become clear that the role of vitamin D goes beyond the regulation of calcium homeostasis and bone health. An important extraskeletal effect of vitamin D is the modulation of the immune system. In the context of autoimmune diseases, this is illustrated by correlations of vitamin D status and genetic polymorphisms in the vitamin D receptor with the incidence and severity of the disease. These correlations warrant investigation into the potential use of vitamin D in the treatment of patients with autoimmune diseases. In recent years, several clinical trials have been performed to investigate the therapeutic value of vitamin D in multiple sclerosis, rheumatoid arthritis, Crohn's disease, type I diabetes, and systemic lupus erythematosus. Additionally, a second angle of investigation has focused on unraveling the molecular pathways used by vitamin D in order to find new potential therapeutic targets. This review will not only provide an overview of the clinical trials that have been performed but also discuss the current knowledge about the molecular mechanisms underlying the immunomodulatory effects of vitamin D and how these advances can be used in the treatment of autoimmune diseases.

Original languageEnglish
Article number697
Number of pages26
JournalFrontiers in Immunology
Volume7
Issue numberJAN
DOIs
Publication statusPublished - 20 Jan 2017
Externally publishedYes

Keywords

  • Autoimmune disease
  • B cells
  • Dendritic cells
  • Macrophages
  • Supplementation
  • T cells
  • Vitamin D

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