Abstract
Vitamin D deficiency has been implicated in the pathophysiology of cardiometabolic disorders including obesity, type 2 diabetes mellitus, cardiovascular diseases and polycystic ovary syndrome. Despite a large number of experimental and observational studies supporting a role for vitamin D in these pathologies, randomized controlled trials have reported little to no effect of vitamin D supplementation in the prevention or treatment of these disorders, although some results remain ambiguous. Polymorphisms in genes related to vitamin D metabolism, particularly in the vitamin D receptor and binding protein and the metabolizing enzyme 1-α-hydroxylase, have emerged as potential contributors to these divergent results. It is now becoming increasingly recognized that the effects and potential benefits of vitamin D supplementation may vary by several factors including vitamin D deficiency status, ethnicity and/or the presence of genetic variants, which affect individual responses to supplementation. However, these factors have seldom been explored in the available literature. Future trials should consider inter-individual differences and, in particular, should aim to clarify whether certain subgroups of individuals may benefit from vitamin D supplementation in the context of cardiometabolic health.
| Original language | English |
|---|---|
| Pages (from-to) | 262-277 |
| Number of pages | 16 |
| Journal | Obesity Reviews |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2019 |
Keywords
- Cardiometabolic disorders
- diabetes
- obesity
- vitamin D
Cite this
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Vitamin D and cardiometabolic disorders : a review of current evidence, genetic determinants and pathomechanisms. / Marquina, Clara; Mousa, Aya; Scragg, Robert; de Courten, Barbora.
In: Obesity Reviews, Vol. 20, No. 2, 02.2019, p. 262-277.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Vitamin D and cardiometabolic disorders
T2 - a review of current evidence, genetic determinants and pathomechanisms
AU - Marquina, Clara
AU - Mousa, Aya
AU - Scragg, Robert
AU - de Courten, Barbora
PY - 2019/2
Y1 - 2019/2
N2 - Vitamin D deficiency has been implicated in the pathophysiology of cardiometabolic disorders including obesity, type 2 diabetes mellitus, cardiovascular diseases and polycystic ovary syndrome. Despite a large number of experimental and observational studies supporting a role for vitamin D in these pathologies, randomized controlled trials have reported little to no effect of vitamin D supplementation in the prevention or treatment of these disorders, although some results remain ambiguous. Polymorphisms in genes related to vitamin D metabolism, particularly in the vitamin D receptor and binding protein and the metabolizing enzyme 1-α-hydroxylase, have emerged as potential contributors to these divergent results. It is now becoming increasingly recognized that the effects and potential benefits of vitamin D supplementation may vary by several factors including vitamin D deficiency status, ethnicity and/or the presence of genetic variants, which affect individual responses to supplementation. However, these factors have seldom been explored in the available literature. Future trials should consider inter-individual differences and, in particular, should aim to clarify whether certain subgroups of individuals may benefit from vitamin D supplementation in the context of cardiometabolic health.
AB - Vitamin D deficiency has been implicated in the pathophysiology of cardiometabolic disorders including obesity, type 2 diabetes mellitus, cardiovascular diseases and polycystic ovary syndrome. Despite a large number of experimental and observational studies supporting a role for vitamin D in these pathologies, randomized controlled trials have reported little to no effect of vitamin D supplementation in the prevention or treatment of these disorders, although some results remain ambiguous. Polymorphisms in genes related to vitamin D metabolism, particularly in the vitamin D receptor and binding protein and the metabolizing enzyme 1-α-hydroxylase, have emerged as potential contributors to these divergent results. It is now becoming increasingly recognized that the effects and potential benefits of vitamin D supplementation may vary by several factors including vitamin D deficiency status, ethnicity and/or the presence of genetic variants, which affect individual responses to supplementation. However, these factors have seldom been explored in the available literature. Future trials should consider inter-individual differences and, in particular, should aim to clarify whether certain subgroups of individuals may benefit from vitamin D supplementation in the context of cardiometabolic health.
KW - Cardiometabolic disorders
KW - diabetes
KW - obesity
KW - vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85057060751&partnerID=8YFLogxK
U2 - 10.1111/obr.12793
DO - 10.1111/obr.12793
M3 - Article
VL - 20
SP - 262
EP - 277
JO - Obesity Reviews
JF - Obesity Reviews
SN - 1467-7881
IS - 2
ER -