Visualization and analysis of a cardio vascular disease- and MUPP1-related biological network combining text mining and data warehouse approaches

Bjorn Sommer, Evgeny S Tiys, Benjamin Kormeier, Klaus Hippe, Sebastian Jan Janowski, Timofey V Ivanisenko, Anatoliy Olegovich Bragin, Patrizio Arrigo, Pavel Sergeevich Demenkov, Alexey Vladimirovich Kochetov, Vladimir Aleksandrovich Ivanisenko, Nikolay Aleksandrovich Kolchanov, Ralf Hofestadt

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7 Citations (Scopus)

Abstract

Detailed investigation of socially important diseases with modern experimental methods has resulted in the generation of large volume of valuable data. However, analysis and interpretation of this data needs application of efficient computational techniques and systems biology approaches. In particular, the techniques allowing the reconstruction of associative networks of various biological objects and events can be useful. In this publication, the combination of different techniques to create such a network associated with an abstract cell environment is discussed in order to gain insights into the functional as well as spatial interrelationships. It is shown that experimentally gained knowledge enriched with data warehouse content and text mining data can be used for the reconstruction and localization of a cardiovascular disease developing network beginning with MUPP1/MPDZ (multi-PDZ domain protein).
Original languageEnglish
Pages (from-to)1 - 26
Number of pages26
JournalJournal of integrative bioinformatics
Volume7
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

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