Visualising coordination chemistry: fluorescence X-ray absorption near edge structure tomography

S. A. James, R. Burke, D. L. Howard, K. M. Spiers, D. J. Paterson, S. Murphy, G. Ramm, R. Kirkham, C. G. Ryan, M. D. de Jonge

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20 Citations (Scopus)


Coordination chemistry underlies the structure/function of biological metal complexes. Contextualising this chemical information within an organism's physiology is critical for enhancing the understanding of bioinorganic chemistry but few high-fidelity probes are available. Here we develop fluorescence X-ray absorption near-edge structure tomography as a means for studying the spatial arrangement of biological coordination chemistry within intact organisms, and demonstrate the approach by mapping the distribution of cuprous and cupric complexes within Drosophila melanogaster.
Original languageEnglish
Pages (from-to)11834-11837
Number of pages4
JournalChemical Communications
Issue number79
Publication statusPublished - 11 Oct 2016

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