Visualising coordination chemistry: fluorescence X-ray absorption near edge structure tomography

S. A. James; R. Burke; D. L. Howard; K. M. Spiers; D. J. Paterson; S. Murphy; G. Ramm; R. Kirkham; C. G. Ryan; M. D. de Jonge

doi:10.1039/C6CC06747F

Visualising coordination chemistry: fluorescence X-ray absorption near edge structure tomography

S. A. James, R. Burke, D. L. Howard, K. M. Spiers, D. J. Paterson, S. Murphy, G. Ramm, R. Kirkham, C. G. Ryan, M. D. de Jonge

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

Coordination chemistry underlies the structure/function of biological metal complexes. Contextualising this chemical information within an organism's physiology is critical for enhancing the understanding of bioinorganic chemistry but few high-fidelity probes are available. Here we develop fluorescence X-ray absorption near-edge structure tomography as a means for studying the spatial arrangement of biological coordination chemistry within intact organisms, and demonstrate the approach by mapping the distribution of cuprous and cupric complexes within Drosophila melanogaster.

Original language	English
Pages (from-to)	11834-11837
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	79
DOIs	https://doi.org/10.1039/C6CC06747F
Publication status	Published - 11 Oct 2016

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10.1039/C6CC06747F

Australian Drosophila Biomedical Research Support Facility
Burke, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/07 → 31/12/13
Project: Research

Monash Micro Imaging
Stephen Firth (Manager), Alex Fulcher (Operator), Oleks Chernyavskiy (Operator), Margaret Rzeszutek (Other), David Potter (Manager), Volker Hilsenstein (Operator), Juan Nunez-Iglesias (Other), Stephen Cody (Manager), Irena Carmichael (Operator), Betty Kouskousis (Other), Sarah Creed (Manager) & Giulia Ballerin (Operator)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility

Cite this

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abstract = "Coordination chemistry underlies the structure/function of biological metal complexes. Contextualising this chemical information within an organism's physiology is critical for enhancing the understanding of bioinorganic chemistry but few high-fidelity probes are available. Here we develop fluorescence X-ray absorption near-edge structure tomography as a means for studying the spatial arrangement of biological coordination chemistry within intact organisms, and demonstrate the approach by mapping the distribution of cuprous and cupric complexes within Drosophila melanogaster.",

author = "James, {S. A.} and R. Burke and Howard, {D. L.} and Spiers, {K. M.} and Paterson, {D. J.} and S. Murphy and G. Ramm and R. Kirkham and Ryan, {C. G.} and {de Jonge}, {M. D.}",

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doi = "10.1039/C6CC06747F",

language = "English",

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AU - James, S. A.

AU - Burke, R.

AU - Howard, D. L.

AU - Spiers, K. M.

AU - Paterson, D. J.

AU - Murphy, S.

AU - Ramm, G.

AU - Kirkham, R.

AU - Ryan, C. G.

AU - de Jonge, M. D.

PY - 2016/10/11

Y1 - 2016/10/11

N2 - Coordination chemistry underlies the structure/function of biological metal complexes. Contextualising this chemical information within an organism's physiology is critical for enhancing the understanding of bioinorganic chemistry but few high-fidelity probes are available. Here we develop fluorescence X-ray absorption near-edge structure tomography as a means for studying the spatial arrangement of biological coordination chemistry within intact organisms, and demonstrate the approach by mapping the distribution of cuprous and cupric complexes within Drosophila melanogaster.

AB - Coordination chemistry underlies the structure/function of biological metal complexes. Contextualising this chemical information within an organism's physiology is critical for enhancing the understanding of bioinorganic chemistry but few high-fidelity probes are available. Here we develop fluorescence X-ray absorption near-edge structure tomography as a means for studying the spatial arrangement of biological coordination chemistry within intact organisms, and demonstrate the approach by mapping the distribution of cuprous and cupric complexes within Drosophila melanogaster.

U2 - 10.1039/C6CC06747F

DO - 10.1039/C6CC06747F

M3 - Article

SN - 1359-7345

VL - 52

SP - 11834

EP - 11837

JO - Chemical Communications

JF - Chemical Communications

IS - 79

ER -

Visualising coordination chemistry: fluorescence X-ray absorption near edge structure tomography

Abstract

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Projects

Australian Drosophila Biomedical Research Support Facility

Equipment

Monash Micro Imaging

Cite this